About this Research Topic
Survival after solid organ transplants is much higher today compared to initial experiences with the procedure. A remarkable evolution occurred with the advent of cyclosporine in the early 80s. Since 1994, some studies have demonstrated the superiority of tacrolimus (TAC), another Cycloneurin inhibitor. Due to this and other factors, such as technical improvement and improvement in intensive care, historical series such as the European Liver Transplant Registry (ELTR) show an increase in survival after the 2000s. Other factors associated with graft loss due to rejection include poor adherence and insufficient immunosuppression (IS).
There is still much room for improvement in outcomes, especially in late follow-up. While current graft survival rates reach up to 85% in the first year of PO, they drop to up to 73% in 5 years, and 61% in 10 years. The main causes of death in the late PO are cardiovascular diseases, malignancies, infections and graft loss due to recurrence of the underlying disease or chronic rejection. In addition, the nephrotoxicity of CI, drugs used to date in almost all receptors, contributes significantly to morbidity and mortality.
The present Research Topic aims to compile articles regarding the following topics in liver transplant:
- immunosuppressive regimens
- short-term and long-term complications
- relapse of underlying disease
There is still much room for improvement in outcomes, especially in late follow-up. While current graft survival rates reach up to 85% in the first year of PO, they drop to up to 73% in 5 years, and 61% in 10 years. The main causes of death in the late PO are cardiovascular diseases, malignancies, infections and graft loss due to recurrence of the underlying disease or chronic rejection. In addition, the nephrotoxicity of CI, drugs used to date in almost all receptors, contributes significantly to morbidity and mortality.
The present Research Topic aims to compile articles regarding the following topics in liver transplant:
- immunosuppressive regimens
- short-term and long-term complications
- relapse of underlying disease
Keywords: Liver Transplantation, Complications, Immunosuppression Therapy, Graft Rejection, Graft Survival, Hepatocellular Carcinoma, Cirrhosis
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