About this Research Topic
The rise of multidrug resistance among the bacterial pathogens has become a major health concern. Earlier this year, WHO has published the list of 12 drug-resistant bacterial pathogens, for which the development of antibacterial drugs with novel modes of action is urgently needed.
Cell division has generated considerable interest as a promising, albeit clinically underexplored antibacterial target. Cell division is a fundamental biological property, and thus many of the divisomal proteins are essential for and ubiquitously present in bacterial species. The main problem in targeting these proteins is in that the main bacterial division proteins have structural homologues among the eukaryotes such as humans ‐FtsZ, which is a structural homologue of tubulin and FtsA has a
similar structure to actin‐,
However, specific experimental inhibitors of bacterial division proteins have been identified that do not affect the human homologues. And finally, the availability of cell‐based phenotypic screening methods, biochemical assays and crystal structures, have made several of these proteins suitable for drug design and screening.
This Research Topic aims attract researchers that are interested in the development of antibiotics that interfere with the mechanisms of cell division. To enable the contributors to benefit from mutually shared ideas and to form new networks of complementary knowledge, we aim to gather new understanding and knowledge on cell division protein target validation and on new cell division inhibitors. Given the urgency of the antibiotic resistance problem, exploring inhibitors that work in synergy with known antibiotics, novel experimental approaches and specific screening assays would be most welcome.
Original research papers, new method descriptions, opinions and reviews covering chemical, biological, biophysical and multidisciplinary approaches are welcome.
Keywords: Antibacterial, Inhibitors, Divisomal Proteins
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