About this Research Topic
Regular physical exercise leads to several health benefits that reduce major risk factors for developing cardiovascular diseases, type II diabetes, hypertension, osteoporosis, cancer, and mental disorders, among others. The relevance of the relation between exercise and health increases when the age-related loss of functionality is considered. Regular exercise improves mitochondria bioenergetic capacity, decreases ROS production, increases antioxidant capacity, decreases DNA damage and protein and lipid oxidation, and stimulates repair mechanisms. Depending on the type of exercise, different cell signaling pathways can be activated and so specific benefits can be achieved. Although the research related to exercise and aging is large, many of the underling mechanisms that explain the outcomes of a specific exercise program are still unknown.
This Research Topic covers the systemic acute and chronic physiological changes induced by exercise that may affect aging. We expect that this compilation of original papers and reviews will provide a better understanding of the molecular mechanisms affected by exercise that induce an increase in organism function and/or a delay in the loss of function with aging. Potential topics include, but are not limited to:
• Signaling pathways induced by different exercise types in skeletal muscle remodeling in elderly.
• Age-related changes in mitochondria plasticity and the role of exercise in the underlying molecular mechanisms.
• DNA damage prevention mechanisms stimulated by exercise and in DNA repair mechanisms.
• Studies on the role of exercise in physiological or pathological molecular mechanisms in the aged brain (examples include Alzheimer and Parkinson disease).
• Studies on the role of exercise in neuro-endocrine changes associated with physiological and pathological aging (examples include Diabetes and osteoporosis).
Keywords: exercise, aging, mitochondria, Dementia, Diabetes
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