About this Research Topic
Population ageing is accelerating worldwide. As per the WHO, ageing population will double by 2050, who are highly susceptible to complex age-related-diseases, the most recent example being COVID-19, representing more economic burden on the medical care systems. Thus, the UN has announced (2020-2030) as the decade of healthy aging in alignment with the last ten years of the SDGs. Despite the presence of different therapeutic strategies, many diseases are spreading in the elderly and are accompanied by therapy resistance. Innate immunity is not only the 1st line of defence, but also coordinates the adaptive immunity. As age progresses, the innate immune system undergoes remodelling; resulting in phenotypic changes and a loss of functional balance termed immunesenescence; contributing towards a loss of protection against pathogens and a defect in homeostatic properties with advancing age. Another feature of ageing is chronic low-grade inflammation and tissue damage development (inflammaging). Moreover, there is an ongoing wave of research supporting the therapeutic role of lifestyle and pharmacological interventions in rejuvenating aged innate immune system to promote healthy ageing.
This topic will address the updates and recent advances in innate immunesenescence; particularly studies focussed on dissecting underlying molecular mechanisms driving these changes during healthy and unhealthy ageing. Together, supporting the development of a better understanding of the crosstalk between the aged innate immune system and the physiological and pathological cellular and acellular microenvironments. Enabling the identification of novel ideas, approaches, and intervention targets to combat innate immunesenescence.
We will be accepting reviews and original articles that identify novel features and underlying molecular mechanisms driving innate immunesenescence and impact on the physiological and pathological conditions in ageing population. This includes research discoveries relating to the aged innate immune system and its crosstalk with the microenvironment, in addition to methodologies (experimental or analytical) that improve the understanding of the development, interpretation, diagnosis or manipulation of innate immunesenescence. Submissions can relate to updates and advances in (but are not limited to):
• Mechanisms and factors contributing towards innate immunesenescence.
• Experimental and analytical methods for analysing and interpreting innate immunesenescence.
• Innate immunesenecence crosstalk with a diseased microenvironment and therapeutic outcomes.
• Therapeutic strategies combatting innate immunesenscence.
This topic will address the updates and recent advances in innate immunesenescence; particularly studies focussed on dissecting underlying molecular mechanisms driving these changes during healthy and unhealthy ageing. Together, supporting the development of a better understanding of the crosstalk between the aged innate immune system and the physiological and pathological cellular and acellular microenvironments. Enabling the identification of novel ideas, approaches, and intervention targets to combat innate immunesenescence.
We will be accepting reviews and original articles that identify novel features and underlying molecular mechanisms driving innate immunesenescence and impact on the physiological and pathological conditions in ageing population. This includes research discoveries relating to the aged innate immune system and its crosstalk with the microenvironment, in addition to methodologies (experimental or analytical) that improve the understanding of the development, interpretation, diagnosis or manipulation of innate immunesenescence. Submissions can relate to updates and advances in (but are not limited to):
• Mechanisms and factors contributing towards innate immunesenescence.
• Experimental and analytical methods for analysing and interpreting innate immunesenescence.
• Innate immunesenecence crosstalk with a diseased microenvironment and therapeutic outcomes.
• Therapeutic strategies combatting innate immunesenscence.
Keywords: Immunesenescence, Inflammaging, aged Innate immune system, healthy ageing, intervention strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
