About this Research Topic
lncRNAs are a class of non-coding RNA involved in various regulatory functions such as transcriptional, post-transcriptional and translation regulation, post-translational modification and, above all, they have an important role in the epigenetic regulation of gene expression. LncRNAs have been broadly identified as key players in chromatin remodeling, histone modification and DNA methylation, directly or as interactors with other effector proteins. It is well known that the onset of cancer is often associated precisely with aberrant epigenetic modifications.
The goal of this research topic is to identify the involvement of lncRNAs in the epigenome reorganization in the onset of cancer. To do this, it would be appropriate to study the epigenetic alterations (degree of DNA methylation, open chromatin regions) associated with various oncological pathologies, both solid and blood cancers, and to understand whether a specific lncRNA may be associated or related to them. Furthermore, it will be necessary to identify any regulators of this process to evaluate any therapies aimed at reducing or re-activating the SUMOylation process according to the identified target.
This Research Topic welcomes Original Research articles and Reviews focusing on the following subjects:
• Identification of new actors in epigenome regulation processes in cancer.
• Evaluation of lncRNAs involvement on epigenome haematological cancer and/or solid cancers.
• Correlation/association on lncRNAs and epigenetic alterations.
• Identification of new lncRNAs able to modified the epigenome in cancer for therapeutic purposes.
• Characterization of specific cancer epigenetic profiles for diagnostics purposes.
The goal of this research topic is to identify the involvement of lncRNAs in the epigenome reorganization in the onset of cancer. To do this, it would be appropriate to study the epigenetic alterations (degree of DNA methylation, open chromatin regions) associated with various oncological pathologies, both solid and blood cancers, and to understand whether a specific lncRNA may be associated or related to them. Furthermore, it will be necessary to identify any regulators of this process to evaluate any therapies aimed at reducing or re-activating the SUMOylation process according to the identified target.
This Research Topic welcomes Original Research articles and Reviews focusing on the following subjects:
• Identification of new actors in epigenome regulation processes in cancer.
• Evaluation of lncRNAs involvement on epigenome haematological cancer and/or solid cancers.
• Correlation/association on lncRNAs and epigenetic alterations.
• Identification of new lncRNAs able to modified the epigenome in cancer for therapeutic purposes.
• Characterization of specific cancer epigenetic profiles for diagnostics purposes.
Keywords: lncRNA, epigenome, cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
