Lipid-immune interplay in chronic inflammatory-based disorders

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ORIGINAL RESEARCH

Published on 02 Apr 2026

Identification of herbal formula Huatanqushihuoxue formula as a potential therapeutic agent for metabolism-related fatty liver disease: a multi-omics and network pharmacology approach

Sutong Liu
Lihui Zhang
Wanyi Zhu
Weichen Ma
Qing Zhao
Minghao Liu
Wenxia Zhao

doi 10.3389/fimmu.2026.1751033

110 views

REVIEW

Published on 23 Mar 2026

Role play of regulatory T cells and resolvins in type 2 diabetes

Sandhya Krishnan
Shriraam Mahadevan
Hanuman Prasad Sharma
Undurti Narasimha Das
Kaviarasan Kuppan

doi 10.3389/fimmu.2026.1748000

221 views

ORIGINAL RESEARCH

Published on 09 Mar 2026

Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study

Huimin Liang
Boqiao Wang
Deyuan Zhang
Zhongzhong Zhang
Xu Chen
Yijia Xu
Chengwei Zhang
Jinyang Li
Jie Yang
3 more
Haize Ge

doi 10.3389/fimmu.2026.1768302

161 views
1 citation

ORIGINAL RESEARCH

Published on 04 Mar 2026

Identification of gemilukast as a bifunctional molecule with lipid-lowering and anti-inflammatory activities

Yuanyuan Liu
Yixiao Wang
Rufei Wang
Qingshan Yang
Guojun Pan
Renshuai Zhang

doi 10.3389/fimmu.2026.1738104

142 views

ORIGINAL RESEARCH

Published on 26 Jan 2026

Lithospermic acid, a novel KLK5 inhibitor, ameliorates rosacea by suppressing the TLR4/NF-κB signaling pathway and rectifying phenylalanine metabolism

Jingang Xu
Xinyu Wang
Manyu Chen
Boya Xu
Tingting Zhang
Yao Zhang
Yueye Xu
Junjie Guo
Jingyun Xu
2 more
Hongming Zhou

doi 10.3389/fimmu.2026.1734997

1,055 views

ORIGINAL RESEARCH

Published on 03 Dec 2025

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

Ya Zhang
Qian Tian
Yuan Zhu
Tianhui Wang
Yongchao Yu
Lan Wang
Lijuan Shao
Xiangang Mo

doi 10.3389/fimmu.2025.1644135

1,693 views

ORIGINAL RESEARCH

Published on 01 Dec 2025

Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury

Sean O’Leary
Anesh Prasai
Ariadna Robledo
Christopher Thang
Ye Wang
Rahul R. Deshpande
William K. Russell
Andrew J. Murton
Steven E. Wolf
Amina El Ayadi

doi 10.3389/fimmu.2025.1709256

1,530 views
1 citation

ORIGINAL RESEARCH

Published on 25 Aug 2025

The relationship between dyslipidemia and chronic liver disease, with the mediating role of depressive symptoms

Wencheng Li
Youlan Zhou
Qingni Li
Deqiang Wang

doi 10.3389/fpubh.2025.1581622

3,225 views
1 citation

ORIGINAL RESEARCH

Published on 22 Jul 2025

Regulation of hepatic Sirt1 expression and lipid metabolism through TNF receptor signaling

Ian N. Hines
Samuel B. Stafford
Blair U. Bradford
Michael D. Wheeler

doi 10.3389/fimmu.2025.1627433

2,421 views
1 citation

REVIEW

Published on 25 Jun 2025

TREM2 in MASH: integrating lipid metabolism and immune response

Shuyi Shi
Yangyang Zhou
Haiming Zhang
Junli Zhang

doi 10.3389/fimmu.2025.1604837

5,941 views
9 citations

REVIEW

Published on 11 Mar 2025

Research progress on AMPK in the pathogenesis and treatment of MASLD

Jiang Feng
Li MengHuan
Yao TingTing
Yi XueJie
Gao HaiNing

doi 10.3389/fimmu.2025.1558041

8,106 views
21 citations

HYPOTHESIS AND THEORY

Published on 01 Nov 2024

Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy

Krishna Rao Maddipati

doi 10.3389/fimmu.2024.1460302

9,388 views
15 citations

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Articles

Identification of herbal formula Huatanqushihuoxue formula as a potential therapeutic agent for metabolism-related fatty liver disease: a multi-omics and network pharmacology approach

Role play of regulatory T cells and resolvins in type 2 diabetes

Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study

Identification of gemilukast as a bifunctional molecule with lipid-lowering and anti-inflammatory activities

Lithospermic acid, a novel KLK5 inhibitor, ameliorates rosacea by suppressing the TLR4/NF-κB signaling pathway and rectifying phenylalanine metabolism

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury

The relationship between dyslipidemia and chronic liver disease, with the mediating role of depressive symptoms

Regulation of hepatic Sirt1 expression and lipid metabolism through TNF receptor signaling

TREM2 in MASH: integrating lipid metabolism and immune response

Research progress on AMPK in the pathogenesis and treatment of MASLD

Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy

Frontiers in Immunology

Inflammation