Bacterial infections remain a leading cause of morbidity and mortality in newborns. Bacterial infections have a higher incidence in the neonatal period than at any other pediatric age. Premature newborns are at the highest risk, with greater incidence of complications including mortality. Common bacterial pathogens infecting neonates include group B Streptococcus and Escherichia coli. Other Gram-positive bacteria causing infections in newborns include Staphylococcus aureus, coagulase-negative staphylococci, enterococci, and Listeria monocytogenes. Additional Gram-negative bacteria that cause of neonatal infections include Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp. and Serratia spp. Finally, the incidence of neonatal syphilis has increased around the world, with associated severe long-term disability in survivors.
While knowledge on the pathogenesis of bacterial neonatal infections has advanced in the last decades, the pathogen and host factors that increase the susceptibility of newborns to bacterial infections are incompletely understood. Consequently, methods for preventing these infections and their adverse consequences are scarce and continue to be a topic of intense investigation.
In this Research Topic, we aim at increasing the understanding of molecular pathogenesis of bacterial infections in newborns. We also seek manuscripts describing novel findings relevant to neonatal immune responses to bacterial pathogens. Investigations related to innovative methods to diagnose, prevent, and treat neonatal bacterial infections will be welcomed as well.
Submissions including Original Research, Review, and Mini Review articles related to the following topics are highly encouraged:
• Innate and adaptive immune responses to bacterial pathogens that commonly infect newborns
• Interactions of bacterial pathogens with host epithelial barriers.
• Bacterial genomic virulence factors relevant to the pathogenesis of neonatal bacterial infections.
• Novel preventive and treatment interventions against bacterial infections in newborns.
• Mechanisms by which probiotics and prebiotics modulate host responses to bacterial pathogens in newborns
Keywords:
Infant, Newborn, Bacterial Infections, Escherichia coli, Streptococcus agalactiae, Syphilis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Bacterial infections remain a leading cause of morbidity and mortality in newborns. Bacterial infections have a higher incidence in the neonatal period than at any other pediatric age. Premature newborns are at the highest risk, with greater incidence of complications including mortality. Common bacterial pathogens infecting neonates include group B Streptococcus and Escherichia coli. Other Gram-positive bacteria causing infections in newborns include Staphylococcus aureus, coagulase-negative staphylococci, enterococci, and Listeria monocytogenes. Additional Gram-negative bacteria that cause of neonatal infections include Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp. and Serratia spp. Finally, the incidence of neonatal syphilis has increased around the world, with associated severe long-term disability in survivors.
While knowledge on the pathogenesis of bacterial neonatal infections has advanced in the last decades, the pathogen and host factors that increase the susceptibility of newborns to bacterial infections are incompletely understood. Consequently, methods for preventing these infections and their adverse consequences are scarce and continue to be a topic of intense investigation.
In this Research Topic, we aim at increasing the understanding of molecular pathogenesis of bacterial infections in newborns. We also seek manuscripts describing novel findings relevant to neonatal immune responses to bacterial pathogens. Investigations related to innovative methods to diagnose, prevent, and treat neonatal bacterial infections will be welcomed as well.
Submissions including Original Research, Review, and Mini Review articles related to the following topics are highly encouraged:
• Innate and adaptive immune responses to bacterial pathogens that commonly infect newborns
• Interactions of bacterial pathogens with host epithelial barriers.
• Bacterial genomic virulence factors relevant to the pathogenesis of neonatal bacterial infections.
• Novel preventive and treatment interventions against bacterial infections in newborns.
• Mechanisms by which probiotics and prebiotics modulate host responses to bacterial pathogens in newborns
Keywords:
Infant, Newborn, Bacterial Infections, Escherichia coli, Streptococcus agalactiae, Syphilis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.