Uncontrolled growth is a major feature of cancer cells and results from diverse genetic alterations that ultimately converge in a constant signal to growth. In addition, cancer cells need a constant supply of nutrients to generate biomass, therefore, many of these genetic alterations also drive changes in the metabolism, enabling uncontrolled growth.
Despite the advances in understanding cancer metabolism, more research is needed to disentangle its complexity.
As many cancer therapies benefit only a subset of patients. Thus, identification of patients belonging to specific subtypes of cancer is crucial for personalized therapies. Moreover, early detection of cancer significantly increases treatment outcomes. As the metabolic alterations occurring in cancer lead to the consumption and release of molecules into the blood, their identification could be useful in early detection and serve as predictive biomarkers. These biomarkers and a better understanding of the pathways highly active in cancer will pave the way for precision medicine approaches.
The aim of this Research Topic is to invite authors to contribute manuscripts describing novel primary data, perspectives, and reviews covering how a better understanding of metabolism will improve therapeutic strategies and the identification of novel biomarkers in cancer.
Potential topics include but are not limited to the following:
• New strategies to target metabolic pathways for cancer treatment
• Novel links between cell signaling and metabolic pathways
• Identification of biomarkers for specific cancer types
• Cation channels in cell signaling and metabolism
• Novel methodologies to detect or improve the detection of polar and non-polar metabolites involved in cancer biology
• Novel links between ferroptosis and metabolism
We accept different article types including Mini-Reviews, Brief Research Reports, and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
Keywords:
Metabolism, Cancer, Cell Signaling, Biomarkers, Metabolomics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Uncontrolled growth is a major feature of cancer cells and results from diverse genetic alterations that ultimately converge in a constant signal to growth. In addition, cancer cells need a constant supply of nutrients to generate biomass, therefore, many of these genetic alterations also drive changes in the metabolism, enabling uncontrolled growth.
Despite the advances in understanding cancer metabolism, more research is needed to disentangle its complexity.
As many cancer therapies benefit only a subset of patients. Thus, identification of patients belonging to specific subtypes of cancer is crucial for personalized therapies. Moreover, early detection of cancer significantly increases treatment outcomes. As the metabolic alterations occurring in cancer lead to the consumption and release of molecules into the blood, their identification could be useful in early detection and serve as predictive biomarkers. These biomarkers and a better understanding of the pathways highly active in cancer will pave the way for precision medicine approaches.
The aim of this Research Topic is to invite authors to contribute manuscripts describing novel primary data, perspectives, and reviews covering how a better understanding of metabolism will improve therapeutic strategies and the identification of novel biomarkers in cancer.
Potential topics include but are not limited to the following:
• New strategies to target metabolic pathways for cancer treatment
• Novel links between cell signaling and metabolic pathways
• Identification of biomarkers for specific cancer types
• Cation channels in cell signaling and metabolism
• Novel methodologies to detect or improve the detection of polar and non-polar metabolites involved in cancer biology
• Novel links between ferroptosis and metabolism
We accept different article types including Mini-Reviews, Brief Research Reports, and Perspectives. A full list of accepted article types, including descriptions, can be found at this
link.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
Keywords:
Metabolism, Cancer, Cell Signaling, Biomarkers, Metabolomics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.