About this Research Topic
From the earliest days of medicine it has been appreciated that there is a physiological response to infection, the most commonly reported being fever and tachycardia. Cardiac dysfunction and respiratory distress have been associated with increased mortality from infectious disease. Animal studies have replicated what has been reported in humans. This Research Topic will look at the relationship between physiological response and outcome in small and large animal models of human infectious diseases.
Electrocardiogram and echocardiogram have been used to study changes in cardiac function. Plethysmography can evaluate respiratory changes associated with not just bacterial or viral pneumonia but viral encephalitis. Radiotelemetry implants allow for continuous monitoring of physiological responses in awake, conscious animals. This eliminates concerns over restraint or anesthesia impacting interpretation of physiological changes. Modern devices are minimally invasive and allow for longitudinal studies in multiple animals simultaneously, including social housing. Monitoring options range from simple (core body temperature) to complex functions such as measuring pressure (blood pressure, pleural pressure) or biopotential (ECG, EEG, EOG).
Although radiotelemetry has mostly been used in biodefense, it has recently been applied to the study of infectious diseases. Radiotelemetry has been used to characterize existing and newly developed disease models, identify biomarkers or correlates of disease that might translate to the human condition, seek potential triggers for therapeutic intervention, and determine efficacy of medical countermeasures. This Research Topic will highlight the application of radiotelemetry, plethysmography and other modalities for studying physiological responses to infectious diseases and the underlying mechanisms behind these responses in animal models.
Keywords: Infectious disease, fever, respiratory, heart, animal model
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