Lipid metabolism is always in dynamic equilibrium, including the biosynthesis and degradation of lipids, both of which play important roles in systemic metabolism homeostasis. The homeostasis of lipid metabolism, if broken, will lead to an increased risk of developing metabolic diseases, such as obesity, diabetes, insulin resistance, non-alcoholic fatty liver disease, atherosclerosis and even cancers. Environment pollution induced (such as insecticides, perfluorinated compounds, antibiotics, microplastics, etc.) and physiological events adapted (such as natural aging, gestation, parturition, lactation, etc.) to lipid metabolism reprogramming, commonly dysregulate metabolic homeostasis in animals and humans, causing suboptimal health and a range of diseases. Due to the imbalance between fat mobilization and fat storage, the occurrence of disease-related lipid metabolism disorders is increasing across the world, seriously affecting the normal functions of adipose, liver, kidney, and other organs. Therefore, from the perspective of environmental exposure and physiological adaptation, clarifying the mechanisms of fat synthesis, transport, metabolism and other related processes in animals or humans is of great significance for improving their health.
Hence, the goal of this Research Topic, “Molecular mechanisms of lipid metabolism reprogramming caused by environmental pollutant exposure and physiological adaptations”, is to focus on the importance of lipid metabolism to human health, especially in the context of environmental pollution exposure and physiologic adaptations.
This Research Topic aims to encourage authors to submit original research articles and review papers related to lipid metabolism in human health and diseases as well as related animal models. Topics may include, but are not limited to:
● The lipid metabolism changes and the corresponding molecular mechanisms in various animals (organs) when exposed to environmental pollutions, such as insecticides, perfluorinated compounds, antibiotics, microplastics, etc;
● The adverse health effects associated with lipid metabolism caused by the related environmental pollutions on animal and human health, such as obesity, diabetes, insulin resistance, non-alcoholic fatty liver disease, atherosclerosis, as well as cancers;
● The reprogramming of lipid metabolism during various physiological events, such as natural aging, gestation, parturition, and lactation;
● The changes in lipid metabolites or other associated metabolites during environmental pollutant exposure and physiological adaptations, and their roles in the regulation of systemic metabolism homeostasis;
● The evidence from clinical data that can provide a new perspective in regulating the homeostasis of lipid metabolism, within the context of environmental pollutant exposure and physiological adaptations.
Keywords:
Environmental toxicity, physiological stimuli, metabolic reprogramming, systemic metabolism homeostasis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Lipid metabolism is always in dynamic equilibrium, including the biosynthesis and degradation of lipids, both of which play important roles in systemic metabolism homeostasis. The homeostasis of lipid metabolism, if broken, will lead to an increased risk of developing metabolic diseases, such as obesity, diabetes, insulin resistance, non-alcoholic fatty liver disease, atherosclerosis and even cancers. Environment pollution induced (such as insecticides, perfluorinated compounds, antibiotics, microplastics, etc.) and physiological events adapted (such as natural aging, gestation, parturition, lactation, etc.) to lipid metabolism reprogramming, commonly dysregulate metabolic homeostasis in animals and humans, causing suboptimal health and a range of diseases. Due to the imbalance between fat mobilization and fat storage, the occurrence of disease-related lipid metabolism disorders is increasing across the world, seriously affecting the normal functions of adipose, liver, kidney, and other organs. Therefore, from the perspective of environmental exposure and physiological adaptation, clarifying the mechanisms of fat synthesis, transport, metabolism and other related processes in animals or humans is of great significance for improving their health.
Hence, the goal of this Research Topic, “Molecular mechanisms of lipid metabolism reprogramming caused by environmental pollutant exposure and physiological adaptations”, is to focus on the importance of lipid metabolism to human health, especially in the context of environmental pollution exposure and physiologic adaptations.
This Research Topic aims to encourage authors to submit original research articles and review papers related to lipid metabolism in human health and diseases as well as related animal models. Topics may include, but are not limited to:
● The lipid metabolism changes and the corresponding molecular mechanisms in various animals (organs) when exposed to environmental pollutions, such as insecticides, perfluorinated compounds, antibiotics, microplastics, etc;
● The adverse health effects associated with lipid metabolism caused by the related environmental pollutions on animal and human health, such as obesity, diabetes, insulin resistance, non-alcoholic fatty liver disease, atherosclerosis, as well as cancers;
● The reprogramming of lipid metabolism during various physiological events, such as natural aging, gestation, parturition, and lactation;
● The changes in lipid metabolites or other associated metabolites during environmental pollutant exposure and physiological adaptations, and their roles in the regulation of systemic metabolism homeostasis;
● The evidence from clinical data that can provide a new perspective in regulating the homeostasis of lipid metabolism, within the context of environmental pollutant exposure and physiological adaptations.
Keywords:
Environmental toxicity, physiological stimuli, metabolic reprogramming, systemic metabolism homeostasis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.