About this Research Topic
The body's defense mechanism has intricately evolved to employ a diverse array of cells and molecules that recognize and respond to external threats. This orchestrated network, known as the immune system, operates dynamically to protect against various foreign invaders including parasites, bacteria, and viruses. Within innate mucosal immunity, key recognition receptor molecules, including toll-like receptors, NOD-like receptors, and RIG-I-like receptors, play pivotal roles in effectively identifying invading pathogens. They trigger immune responses to impede entry and neutralize potential tissue damage, while also regulating adaptive responses during severe infections and contributing to the formation of a memory response. Given that most infections occur through the mucosa, understanding the initial host defense response at the mucosal surface is crucial for infection control and overall system protection.
The host immune system successfully controls the population of many microbes and prevents the mucosal microbiomes from invading host tissue. However, many microbes circumvent the immune system and/or induce an inappropriate and harmful response. It is thus imperative to understand these exploitable failures in host immunity. By augmenting the immune response to account for these shortcomings, innovations in targeting mucosal immunology hold the promise of effective therapeutics against pathogens.
This Research Topic accepts Original Research, Systematic Review, Methods, Review and Mini-Review, Hypothesis & Theory, Clinical Trial, Classification, Technology and Code, Study Protocol, Perspective, Case Report, Conceptual Analysis, Curriculum, Instruction, and, Brief Research Report, Data Report, General Commentary, Opinion. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• The effects and functions of diverse innate mucosal agents: immune cells, signaling molecules, and cell-to-cell interactions
• Physiological immune responses of the gut to bacterial, viral, parasitic infections
• Physiological immune responses of the lungs to bacterial, viral, parasitic infections
• Development of innovative interventions for mucosal diseases
The host immune system successfully controls the population of many microbes and prevents the mucosal microbiomes from invading host tissue. However, many microbes circumvent the immune system and/or induce an inappropriate and harmful response. It is thus imperative to understand these exploitable failures in host immunity. By augmenting the immune response to account for these shortcomings, innovations in targeting mucosal immunology hold the promise of effective therapeutics against pathogens.
This Research Topic accepts Original Research, Systematic Review, Methods, Review and Mini-Review, Hypothesis & Theory, Clinical Trial, Classification, Technology and Code, Study Protocol, Perspective, Case Report, Conceptual Analysis, Curriculum, Instruction, and, Brief Research Report, Data Report, General Commentary, Opinion. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• The effects and functions of diverse innate mucosal agents: immune cells, signaling molecules, and cell-to-cell interactions
• Physiological immune responses of the gut to bacterial, viral, parasitic infections
• Physiological immune responses of the lungs to bacterial, viral, parasitic infections
• Development of innovative interventions for mucosal diseases
Keywords: Innate immunity, ILCs in mucosa, Myeloid cells in gut diseases, mucosal immunity, innate cells in lungs infection
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