Fibrosis, characterized by the replacement of normal tissue with permanent scar tissue, is a critical process in the pathology of chronic diseases affecting major organs. It typically results from continuous inflammation or damage leading to an excess of fibrous connective tissue and a reduction in functional parenchymal cells. As fibrosis progresses, it can cause severe structural damage and functional decline in organs such as the lungs, liver, brain, and heart, potentially leading to organ failure and increased mortality. Recent studies underline fibrosis as a significant contributor to the morbidity and mortality associated with various organ diseases, pointing to a dire need for comprehensive research into its pathogenesis and management.
Following the previous topic: https://www.frontiersin.org/research-topics/35016/fibrotic-diseases-in-thorax-and-abdomainal-viscera-volume-ii/magazine, this research topic aims to explore the pathogenesis and pathophysiological process of fibrotic diseases in lungs, liver, brain, kidneys, bones, skin, eyes, prostate, and heart., as well as clinical case diagnosis and treatment research, including genome-wide screening of disease-related functional genes, pathogenesis, screening of susceptible populations, early diagnosis, pathological analysis, screening of therapeutic targets, and new drugs development and related research.
To gather further insights into the broad ramifications of fibrosis, we welcome articles addressing, but not limited to, the following themes:
Nature, etiology, and pathophysiology of fibrotic disorders
Biologically relevant aspects of epidemiology, diagnosis, and treatment
Drug discovery and development processes pertaining to fibrosis
Innovations in basic and clinical pharmacology related to fibrotic treatments
In this Research Topic, we encourage submissions of original research articles and review papers.
Fibrosis, characterized by the replacement of normal tissue with permanent scar tissue, is a critical process in the pathology of chronic diseases affecting major organs. It typically results from continuous inflammation or damage leading to an excess of fibrous connective tissue and a reduction in functional parenchymal cells. As fibrosis progresses, it can cause severe structural damage and functional decline in organs such as the lungs, liver, brain, and heart, potentially leading to organ failure and increased mortality. Recent studies underline fibrosis as a significant contributor to the morbidity and mortality associated with various organ diseases, pointing to a dire need for comprehensive research into its pathogenesis and management.
Following the previous topic: https://www.frontiersin.org/research-topics/35016/fibrotic-diseases-in-thorax-and-abdomainal-viscera-volume-ii/magazine, this research topic aims to explore the pathogenesis and pathophysiological process of fibrotic diseases in lungs, liver, brain, kidneys, bones, skin, eyes, prostate, and heart., as well as clinical case diagnosis and treatment research, including genome-wide screening of disease-related functional genes, pathogenesis, screening of susceptible populations, early diagnosis, pathological analysis, screening of therapeutic targets, and new drugs development and related research.
To gather further insights into the broad ramifications of fibrosis, we welcome articles addressing, but not limited to, the following themes:
Nature, etiology, and pathophysiology of fibrotic disorders
Biologically relevant aspects of epidemiology, diagnosis, and treatment
Drug discovery and development processes pertaining to fibrosis
Innovations in basic and clinical pharmacology related to fibrotic treatments
In this Research Topic, we encourage submissions of original research articles and review papers.