Research Topic

Cardiovascular Instability in the Preterm Infant

About this Research Topic

Despite significant advances in other areas of newborn care, little has changed in our approach to the management of preterm infants with low blood pressure in the first days of life. Recent surveys conducted in Europe, Canada and Australia have highlighted the continued reliance of clinicians on an approach characterized by targeting blood pressure (BP) values, in particular the mean arterial BP, as a surrogate of cardiovascular well-being. The reliance on BP as a surrogate of cardiovascular well-being remains problematic on a number of levels.

In this Research Topic we will provide further insight into the complexities involved in newborn cardiovascular assessment and management at the bedside. These state of the art reviews will explore the relationship between blood pressure and brain injury in preterm infants, assess the role of objective monitoring tools such as echocardiography, near infrared spectroscopy and EEG in determining the adequacy of circulatory well being. We will explore the use of inotropes, including an understanding of the pharmacokinetic and pharmacodynamic aspects of various inotrope/inodilators commonly used, and will also address aspects of drug delivery in preterm infants. The concept of multimodal monitoring systems, including mechanisms of data acquisition, analysis and integration as into individualized targeted therapy regimes will be explored.


Keywords: Hypotension, echocardiography, inotropes, intraventricular hemorrhage


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Despite significant advances in other areas of newborn care, little has changed in our approach to the management of preterm infants with low blood pressure in the first days of life. Recent surveys conducted in Europe, Canada and Australia have highlighted the continued reliance of clinicians on an approach characterized by targeting blood pressure (BP) values, in particular the mean arterial BP, as a surrogate of cardiovascular well-being. The reliance on BP as a surrogate of cardiovascular well-being remains problematic on a number of levels.

In this Research Topic we will provide further insight into the complexities involved in newborn cardiovascular assessment and management at the bedside. These state of the art reviews will explore the relationship between blood pressure and brain injury in preterm infants, assess the role of objective monitoring tools such as echocardiography, near infrared spectroscopy and EEG in determining the adequacy of circulatory well being. We will explore the use of inotropes, including an understanding of the pharmacokinetic and pharmacodynamic aspects of various inotrope/inodilators commonly used, and will also address aspects of drug delivery in preterm infants. The concept of multimodal monitoring systems, including mechanisms of data acquisition, analysis and integration as into individualized targeted therapy regimes will be explored.


Keywords: Hypotension, echocardiography, inotropes, intraventricular hemorrhage


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 November 2017 Manuscript
15 December 2017 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 November 2017 Manuscript
15 December 2017 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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