About this Research Topic
Evidence of widespread cognitive impairment and psychological changes is well-established in the adult temporal lobe epilepsy (TLE) literature, and similar cognitive impairment in children with TLE is becoming more evident. The pediatric TLE literature has frequently focused on potential surgical options of therapy and therefore documented findings are often limited to cognitive domains associated with the temporal lobe. As such, there is substantial evidence of episodic memory impairment in children with TLE. There is also emerging evidence of abnormal language development in children with TLE suggesting that neural network development may be altered early in the course of the disorder. Based on the fact that (1) adults with TLE show widespread cognitive impairment in regions outside of the temporal lobe; (2) children with TLE exhibit neural network alterations early in the course of the disease and (3) adults with childhood onset TLE perform far worse on comprehensive neuropsychological test batteries compared to adults with adult onset TLE, it begs the question, does the cognitive impairment occur earlier in the onset of the disease and does it affect regions beyond the temporal lobe? Recently, researchers have begun to evaluate for cognitive impairment outside of the temporal lobe in pediatric TLE and we find that children with TLE do indeed exhibit cognitive impairment in multiple major cognitive domains. Currently, psychiatric comorbidities and cognitive impairments are recognized as epiphenomena of an abnormal brain in patients with epilepsy. Psychiatric comorbidities in patients with TLE includes symptoms of attention deficit hyperactivity disorder (ADHD), depression, anxiety and other mood concerns.
The goal of this Research Topic is to incorporate and synthesize the current literature available regarding cognitive impairment and psychological co-morbidities in children with TLE in order to determine what has been done and what further research needs to focus on to achieve a better overall understanding of the field.
Keywords: Temporal lobe epilepsy, Children, Cognitive impairment, Neural network alterations, Psychiatric co-morbidities
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