About this Research Topic
Iron is essential for a wide variety of the metabolic processes of living organisms, due to its chemical transitional property: it has both ferrous (Fe2+) and ferric (Fe3+) states, which can donate and accept electrons, respectively. Iron is present in the different forms of heme and the iron-sulfur (Fe-S) cluster binding protein, which plays an important role in various enzymatic reactions such as aerobic respiration, TCA-cycle function and DNA synthesis as well as oxygen transport and storage.
2.7 billion years ago, the appearance of photosynthetic organisms made possible the subsequent evolution of systems that utilize glucose and produce ATP by oxidative phosphorylation using the pre-existing glycolytic pathway. Therefore, this evolution must be understood as a pivotal event. However, the failure of electron transport produces reactive oxygen species (ROS), therefore living organisms have developed anti-oxidant mechanisms against ROS by effective scavengers such as vitamins C and E or enzyme reaction by catalase, super oxide dismutase, glutathione peroxidase, etc. Although iron is tightly controlled, excess free iron (Fe2+) deteriorates oxidative stress to produce most toxic hydroxyl radical by Fenton reaction.
In this Research Topic, we seek articles that address the following aspects of the role of iron in animal energy metabolism:
• cellular and mitochondrial iron metabolism
• oxidative stress
• inherited disorders of iron metabolism
• cross-talk between iron metabolism and metabolic diseases such as diabetes and lipidosis
Keywords: electron transport system, Iron, mitochondria, oxidative stress, oxidative phosphorylation
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