Research Topic

Complex Immune Mediated Pulmonary Disease: How Genetic Data can Influence Clinical Practice

About this Research Topic

In the advent of genome explorations based on single nucleotide polymorphisms (SNPs) and next generation sequencing (NGS) technologies during the last decade, new knowledge on the role of genetic variation has been the key element in the advancement of pulmonary medicine.

Information obtained from the human genome importantly contributes to understanding the etiopathogenesis of complex pulmonary disease with immune (inflammatory, autoimmune) features, which range from frequent disorders such as COPD or asthma bronchiale to less frequent disease such as sarcoidosis or idiopathic pulmonary fibrosis. While there have been numerous reports on disease susceptibility or protective variants, only recently genetic data have been related to distinct phases of the disease course or to specific phenotypes and endotypes.

Therefore, at present there is an urgent need for translation of these finding to clinical practice. Application of genetic data for disease stratification, prognostication and last but not least for assessment of treatment response is desirable. In this context, providing evidence whether and how environmental interactions or epigenetic factors could be utilized for these purposes also deserves investigation.

The aim of this research topic is to provide state of the art knowledge on translational genetics of complex, immune-mediated respiratory disease with and to delineate areas for further research in this field. Contributions from investigators in respiratory medicine and related disciplines, not limited to immunology, genetics, bioinformatics, medical databases and big data analysis would be welcome in any manuscript format. Given the topic, we stimulate multi-disciplinary and multi-center contributions. The ultimate goal would be to present, discuss and share the results, methods and approaches and in this way to help moving forward the process of translating genetic findings into clinical management of complex pulmonary diseases.


Keywords: pulmonary translational medicine, genetic variation, prediction, disease course, personalized medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

In the advent of genome explorations based on single nucleotide polymorphisms (SNPs) and next generation sequencing (NGS) technologies during the last decade, new knowledge on the role of genetic variation has been the key element in the advancement of pulmonary medicine.

Information obtained from the human genome importantly contributes to understanding the etiopathogenesis of complex pulmonary disease with immune (inflammatory, autoimmune) features, which range from frequent disorders such as COPD or asthma bronchiale to less frequent disease such as sarcoidosis or idiopathic pulmonary fibrosis. While there have been numerous reports on disease susceptibility or protective variants, only recently genetic data have been related to distinct phases of the disease course or to specific phenotypes and endotypes.

Therefore, at present there is an urgent need for translation of these finding to clinical practice. Application of genetic data for disease stratification, prognostication and last but not least for assessment of treatment response is desirable. In this context, providing evidence whether and how environmental interactions or epigenetic factors could be utilized for these purposes also deserves investigation.

The aim of this research topic is to provide state of the art knowledge on translational genetics of complex, immune-mediated respiratory disease with and to delineate areas for further research in this field. Contributions from investigators in respiratory medicine and related disciplines, not limited to immunology, genetics, bioinformatics, medical databases and big data analysis would be welcome in any manuscript format. Given the topic, we stimulate multi-disciplinary and multi-center contributions. The ultimate goal would be to present, discuss and share the results, methods and approaches and in this way to help moving forward the process of translating genetic findings into clinical management of complex pulmonary diseases.


Keywords: pulmonary translational medicine, genetic variation, prediction, disease course, personalized medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

26 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

26 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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