About this Research Topic
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), represent critical conditions characterized by pulmonary inflammation, endothelial injury, and severe hypoxemia. Despite advancements in supportive care, the morbidity and mortality associated with these conditions remain high. The pulmonary endothelium plays a pivotal role in the pathogenesis of ALI/ARDS, orchestrating the intricate interplay between inflammation, coagulation, and vascular permeability. Understanding the molecular mechanisms underlying endothelial dysfunction and identifying novel therapeutic targets are paramount to improving outcomes in ALI/ARDS patients.
This Research Topic aims to explore the challenges and opportunities in targeting pulmonary endothelium to ameliorate ALI/ARDS. We seek to delve into the complexities of endothelial cell biology within the context of lung injury, shedding light on the pathophysiological processes that can be manipulated to restore pulmonary homeostasis. Recent advances have underscored the significance of endothelial cells in modulating inflammation, vascular tone, and fluid balance, offering new avenues for therapeutic intervention. Through this special issue, we aim to compile a comprehensive overview of the current strategies, emerging therapies, and innovative research that are shaping the future of ALI/ARDS management.
We welcome original research articles, reviews, and brief communications that address the following themes related to ALI/ARDS:
• The role of endothelial cells in the initiation and progression of ALI/ARDS.
• Molecular pathways contributing to endothelial barrier dysfunction.
• The interplay between the endothelium and immune cells in the alveolar space.
• Novel biomarkers for early detection and prognosis of endothelial damage.
• Therapeutic strategies targeting endothelial cell activation and repair.
• The impact of co-morbidities on endothelial function in the context of ALI/ARDS.
• Translational studies that bridge basic research with clinical applications.
We are particularly interested in manuscripts that present innovative approaches to modulate endothelial function, including gene therapy, nanomedicine, and repurposing of existing drugs. Additionally, we encourage the submission of articles that utilize cutting-edge technologies like organ-on-a-chip models, single-cell RNA sequencing, and bioinformatics to elucidate endothelial cell behavior in ALI/ARDS.
This Research Topic aims to explore the challenges and opportunities in targeting pulmonary endothelium to ameliorate ALI/ARDS. We seek to delve into the complexities of endothelial cell biology within the context of lung injury, shedding light on the pathophysiological processes that can be manipulated to restore pulmonary homeostasis. Recent advances have underscored the significance of endothelial cells in modulating inflammation, vascular tone, and fluid balance, offering new avenues for therapeutic intervention. Through this special issue, we aim to compile a comprehensive overview of the current strategies, emerging therapies, and innovative research that are shaping the future of ALI/ARDS management.
We welcome original research articles, reviews, and brief communications that address the following themes related to ALI/ARDS:
• The role of endothelial cells in the initiation and progression of ALI/ARDS.
• Molecular pathways contributing to endothelial barrier dysfunction.
• The interplay between the endothelium and immune cells in the alveolar space.
• Novel biomarkers for early detection and prognosis of endothelial damage.
• Therapeutic strategies targeting endothelial cell activation and repair.
• The impact of co-morbidities on endothelial function in the context of ALI/ARDS.
• Translational studies that bridge basic research with clinical applications.
We are particularly interested in manuscripts that present innovative approaches to modulate endothelial function, including gene therapy, nanomedicine, and repurposing of existing drugs. Additionally, we encourage the submission of articles that utilize cutting-edge technologies like organ-on-a-chip models, single-cell RNA sequencing, and bioinformatics to elucidate endothelial cell behavior in ALI/ARDS.
Keywords: acute lung injury, ARDS, endothelium, therapeutic approaches, molecular mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
