About this Research Topic
During the diagnostic work up of renal biopsies we oftentimes fail to provide any meaningful guidance regarding etiology, prognosis or prediction of treatment response using the current diagnostic triad of light, immunofluorescence, and electron microscopy. In the age of precision medicine the intricate multi-cellular architecture of the glomerulus as well as the nano-scale structure of the kidney filter greatly limit our ability to perform desperately needed translational studies in glomerular diseases, thereby delaying the development of targeted treatment strategies for our patients. Consequently, there is an unmet need for 1) additional insights into the molecular pathogenesis of those diseases to identify useful biomarkers and 2) companion diagnostics that provide us with the necessary diagnostic resolution to identify molecular signatures of glomerular injury in vivo.
This article collection focuses on soliciting scientific manuscripts about innovative and novel visual tissue interrogation methods with direct applicability to glomerular pathobiology. Those could include, but are not limited to, descriptions of novel methodologies to improve tissue preparation and clearing, use of advanced super resolution microscopy (i.e. SIM, STED, STORM/PALM, etc.), intra-vital imaging techniques for functional analysis (i.e. 2-Photon Microscopy), or computer-based algorithms to analyze and process digital microscopic images, all with the goal to improve any or all of the following: diagnostic resolution, cost, accessibility, or multiplexing ability.
Keywords: High resolution, molecular signatures, glomerular filter, companion diagnostics, precision medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.