About this Research Topic
It has been frequently said that chemotherapeutic drugs are more responsible for major side effects, and in some cases lead to cancer patients’ death. Often, tumor cells develop resistance to chemotherapeutic drugs, leading to inefficient or ineffectual action of the drug on cancer cells—and unregulated action on normal cells.
Several nanoscale drug delivery systems and therapies have recently been developed to tackle this resistance problem, including polymeric nano-micelles (PM), inorganic nanoparticles, and carbon-based nanoparticles. While promising to be particularly capable agents in detecting, diagnosing, and treating cancer, each of these nanomaterials also pose disadvantages, such as toxicity and aggregate formation.
A newly developed, promising strategy to overcome these disadvantages, and to produce perfect theranostics systems for drugs or diagnostic agents, is to make hybrid systems containing all of these nanomaterials: "hybrid nanostructures."
Hybrid nanostructures involve organic-inorganic interfaces such as polymer, protein-functionalized gold, magnetic, superparamagnetic, platinum, carbon and silver nanoparticles. These hybrid nanostructures are the most promising materials for drug loading, drug delivery, cancer imaging (such as MRI, CT, PET), therapy (such as magnetic hyperthermia), and photodynamic therapy against cancer. Hence, the development of hybrid nanostructures opens the way for nanomedicines for various diseases such as cancer, pathogenic infections, neurodegenerative diseases, and many more.
This Research Topic seeks to explore new synthetic routes for the preparation of hybrid nanostructures: their bioconjugation, functionalization, and targeting in cancer theranostics. Along with synthesis, this Research Topic will focus on new outcomes in the field of hybrid nanostructures geared toward tackling cancer and overcoming the limitations of currently used nanomedicines in cancer.
Article themes may include, but are not limited to:
1. Functionalized gold, silver, magnetic, polymer, carbon nanotubes, graphene, lipid, and micellar nanoparticles in cancer drug delivery
2. Magnetic hybrid nanostructures in cancer hyperthermia therapy
3. Hybrid nanostructures and their cellular interactions
4. In vivo implications of hybrid nanostructures
5. Plasmonic hybrid nanostructures (gold, silver) for photodynamic cancer therapy
6. Magneto-plasmonic hybrid nanostructures for multimodal cancer therapy
7. Functional superparamagnetic nanostructures for dual modal magnetic resonance
8. Bioconjugation of hybrid nanostructures in targeted drug delivery
9. Multimodal imaging with functional hybrid nanostructures
10. Hybrid and polymer nanostructures in the Blood Brain Barrier (BBB)
11. Creating hybrid nanostructures with different shapes and sizes through the novel synthesis method and their use in cancer theranostics
Keywords: cancer, functional nanomaterials, magnetic materials, polymers, multimodal imaging