Research Topic

Current Issues in Managing and Treating Thoracic Aortic Diseases

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About this Research Topic

Thoracic aortic diseases (Thoracic Aortic Aneurysm-TAA, and dissection-TAD) represent a life threatening condition with high mortality related to their complications. Medical treatments can slow the enlargement of aneurysms to some extent but a complex surgical repair of the thoracic aorta may be unavoidable to prevent premature death resulting from dissection or rupture. Advances in the evaluation of TAA patients have helped in identifying conditions, such as Marfan Syndrome (MFS) or Bicuspid Aortic Valve disease (BAV), that predispose to a higher risk of aortic dissection/rupture. Improvement in the life expectancy of these patients can be attributed to the early diagnosis, routine echo and computed tomography monitoring of aortic diameter and timely surgical intervention. However, studies have shown that aortic dissections can occur in patients with aortas smaller than the size currently suggested for surgical replacement. Therefore, metric measurements are not accurate predictors of aortic stability and the actual pathological progression as well as the individual risk of adverse events, in patients with aortic diseases, is currently unpredictable. In addition, no adequate therapeutic treatment is available to eliminate the need for surgery for TAA patients. Therefore, more studies are needed in order to ameliorate both the risk stratification and the treatment of patients with these diseases.

For this Research Topic, we welcome investigators to contribute original research articles as well as review articles covering clinical, translational and basic science aspects of thoracic aortic diseases so that they will contribute to the continuing efforts to better understand the underlying pathology and improve outcome in TAA and TAD patients.


Keywords: Thoracic aortic disease, Marfan syndrome, Bicuspid aortic valve disease, Biomarkers, Aortic surgery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Thoracic aortic diseases (Thoracic Aortic Aneurysm-TAA, and dissection-TAD) represent a life threatening condition with high mortality related to their complications. Medical treatments can slow the enlargement of aneurysms to some extent but a complex surgical repair of the thoracic aorta may be unavoidable to prevent premature death resulting from dissection or rupture. Advances in the evaluation of TAA patients have helped in identifying conditions, such as Marfan Syndrome (MFS) or Bicuspid Aortic Valve disease (BAV), that predispose to a higher risk of aortic dissection/rupture. Improvement in the life expectancy of these patients can be attributed to the early diagnosis, routine echo and computed tomography monitoring of aortic diameter and timely surgical intervention. However, studies have shown that aortic dissections can occur in patients with aortas smaller than the size currently suggested for surgical replacement. Therefore, metric measurements are not accurate predictors of aortic stability and the actual pathological progression as well as the individual risk of adverse events, in patients with aortic diseases, is currently unpredictable. In addition, no adequate therapeutic treatment is available to eliminate the need for surgery for TAA patients. Therefore, more studies are needed in order to ameliorate both the risk stratification and the treatment of patients with these diseases.

For this Research Topic, we welcome investigators to contribute original research articles as well as review articles covering clinical, translational and basic science aspects of thoracic aortic diseases so that they will contribute to the continuing efforts to better understand the underlying pathology and improve outcome in TAA and TAD patients.


Keywords: Thoracic aortic disease, Marfan syndrome, Bicuspid aortic valve disease, Biomarkers, Aortic surgery


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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