Cancer drug resistance poses a significant challenge in oncology, undermining the efficacy of chemotherapy, targeted therapy, and immunotherapy. Resistance arises when cancer cells adapt through a myriad of intrinsic and extrinsic factors, enabling them to evade the cytotoxic effects of anticancer agents. Key intrinsic variables include tumor heterogeneity, modified drug efflux and metabolism, and activation of alternative signaling pathways, while the tumor microenvironment plays a crucial role as an extrinsic factor. Despite advancements in understanding these mechanisms, largely due to cutting-edge technologies, a comprehensive grasp of the underlying processes remains incomplete. This gap in knowledge necessitates ongoing research to decode the complexity of drug resistance in cancer.

The goal of this research topic is to consolidate new research that sheds light on the prevention, critical determinants, and remedial strategies against cancer drug resistance. By exploring innovative solutions and identifying key mechanisms of resistance, the research seeks to pave the way for developing more effective therapeutic modalities designed to block or reverse resistance pathways.

To enhance our knowledge within this critical field, this topic welcomes submissions that explore: Cellular, animal model, and clinical cohort studies to unravel and address drug resistance. We encourage contributions across a range of themes, including:

• Unveiling molecular mechanisms that underpin drug resistance in cancer.
• Application of high-throughput analysis for new diagnostic advancements countering drug resistance.
• Development of novel therapeutic strategies aimed at overcoming tumor resistance.

These focused studies are pivotal for crafting targeted interventions that can thwart the mechanisms facilitating drug resistance, ultimately leading to more successful cancer treatment outcomes.

Are you interested in contributing a manuscript to this Research Topic?

Exploring and Overcoming Cancer Drug Resistance: Novel Insights and Strategies