This Research Topic is the second volume of the Research Topic "Herbal Medical Products for Metabolic Diseases - New Integrated Pharmacological Approaches." Please see the first volume (here)Metabolic diseases, such as type 2 diabetes (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), and certain forms of cancer, are among the most prevalent health issues worldwide. These diseases are characterized by altered metabolism and impaired energy homeostasis, leading to chronic disease development. Natural medicines, including plants, herbal extracts, and metabolites, have been used for centuries to treat various ailments and have recently garnered attention as potential therapeutics for metabolic diseases. Clinical and pharmacological approaches play a crucial role in discovering and developing natural remedies for these conditions. In the case of individual metabolites, a combination with computational approaches may be feasible. A thorough understanding of the molecular mechanisms underlying metabolic diseases and the potential benefits of natural remedies can provide valuable insights into new therapeutic targets and treatment options.This Research Topic explores the potential of natural remedies as an alternative approach to treating metabolic diseases such as type 2 diabetes (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), and cancer. Although these diseases have different pathophysiologies, they share common underlying mechanisms, such as insulin resistance, inflammation, and oxidative stress. Despite significant advances in modern medicine, these diseases remain major public health problems worldwide with few effective treatments available.Natural medicines have been used for centuries to treat various ailments, and recent studies suggest they also hold promise for treating metabolic diseases. Clinical and pharmacological approaches can be employed to identify and evaluate the potential of natural remedies as therapeutics for these conditions.The Research Topic aims to bring together researchers and experts from various fields to share their knowledge and expertise. It serves as a platform to discuss recent advances in the identification, assessment, and development of natural medicines as potential treatments for metabolic diseases and to identify future research directions and opportunities within this field.Scope of the Research Topic:• Identification, characterization, and optimization of natural medicines for metabolic diseases.• Preclinical and clinical studies of natural medicines for metabolic diseases.• Combination therapies with natural medicines for metabolic diseases.• Drug delivery and formulation approaches for natural medicines.Please note the following:1. All manuscripts submitted to this project will be peer-reviewed and need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology. Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a and b).2. In silico studies like network analysis or docking studies are outside of the scope of the section and of Frontiers in Pharmacology, unless these approaches are combined with a detailed pharmacological assessment of the hypothesis generated in silico.3. A detailed chemical profile of the extract and pharmacognostic definition of the botanical drugs used is essential, as defined in the ConPhyMP statement 2022.4. All studies must use a therapeutically realistic dose level, and the data must be reported on the basis of the amount of extract administered. Single-dose studies are not accepted unless they focus on a species/compound not yet studied in detail and can be justified on specific ethical grounds (e.g., the 4R rule - Reduce, refine, replace – responsibility, see the Four Pillars).
This Research Topic is the second volume of the Research Topic "Herbal Medical Products for Metabolic Diseases - New Integrated Pharmacological Approaches." Please see the first volume (here)Metabolic diseases, such as type 2 diabetes (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), and certain forms of cancer, are among the most prevalent health issues worldwide. These diseases are characterized by altered metabolism and impaired energy homeostasis, leading to chronic disease development. Natural medicines, including plants, herbal extracts, and metabolites, have been used for centuries to treat various ailments and have recently garnered attention as potential therapeutics for metabolic diseases. Clinical and pharmacological approaches play a crucial role in discovering and developing natural remedies for these conditions. In the case of individual metabolites, a combination with computational approaches may be feasible. A thorough understanding of the molecular mechanisms underlying metabolic diseases and the potential benefits of natural remedies can provide valuable insights into new therapeutic targets and treatment options.This Research Topic explores the potential of natural remedies as an alternative approach to treating metabolic diseases such as type 2 diabetes (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), and cancer. Although these diseases have different pathophysiologies, they share common underlying mechanisms, such as insulin resistance, inflammation, and oxidative stress. Despite significant advances in modern medicine, these diseases remain major public health problems worldwide with few effective treatments available.Natural medicines have been used for centuries to treat various ailments, and recent studies suggest they also hold promise for treating metabolic diseases. Clinical and pharmacological approaches can be employed to identify and evaluate the potential of natural remedies as therapeutics for these conditions.The Research Topic aims to bring together researchers and experts from various fields to share their knowledge and expertise. It serves as a platform to discuss recent advances in the identification, assessment, and development of natural medicines as potential treatments for metabolic diseases and to identify future research directions and opportunities within this field.Scope of the Research Topic:• Identification, characterization, and optimization of natural medicines for metabolic diseases.• Preclinical and clinical studies of natural medicines for metabolic diseases.• Combination therapies with natural medicines for metabolic diseases.• Drug delivery and formulation approaches for natural medicines.Please note the following:1. All manuscripts submitted to this project will be peer-reviewed and need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology. Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a and b).2. In silico studies like network analysis or docking studies are outside of the scope of the section and of Frontiers in Pharmacology, unless these approaches are combined with a detailed pharmacological assessment of the hypothesis generated in silico.3. A detailed chemical profile of the extract and pharmacognostic definition of the botanical drugs used is essential, as defined in the ConPhyMP statement 2022.4. All studies must use a therapeutically realistic dose level, and the data must be reported on the basis of the amount of extract administered. Single-dose studies are not accepted unless they focus on a species/compound not yet studied in detail and can be justified on specific ethical grounds (e.g., the 4R rule - Reduce, refine, replace – responsibility, see the Four Pillars).