In recent years, it has become evident that cell metabolism shapes and is shaped by immune responses highlighting cell metabolism as therapeutic target to modulate chronic inflammation such as in autoimmune and autoinflammatory diseases as well as in cancer. In addition, diverse metabolites were demonstrated to direct immune responses through multiple mechanisms, often through cognate G protein-coupled receptor. Traditionally viewed through separate lenses, the metabolic mechanisms and immune system responses are now recognized as co-dependent, with an intricate relationship influencing disease outcomes. Chronic inflammation, a hallmark of both autoimmune and autoinflammatory diseases, as well as cancer, exemplifies the critical role metabolism plays in disease etiology and progression. This revelation springs from breakthrough studies revealing the regulatory roles of diverse bioactive metabolites in steering immune responses, often acting through G protein-coupled receptors. These findings underscore the necessity to delve deeper into the metabolic pathways influencing inflammation and disease.

This Research Topic aims to cast a spotlight on the intrinsic link between cell metabolism and its influence on chronic inflammatory conditions, with a dual focus on illuminating the scientific understanding of this phenomenon and evaluating its potential as a strategic therapeutic target. Key aspects include interrogating the mechanisms by which metabolism affects immune cell function in the context of chronic diseases and identifying metabolic interventions that could mitigate or reverse these conditions. By dissecting the metabolic underpinnings, the goal is to establish a critical framework for developing targeted therapies that modulate metabolic pathways, thus providing new strategies for managing or curing inflammation-related diseases.

To ensure a comprehensive examination of this complex and multifaceted topic, this guest collection invites contributions that extend across several research dimensions:

-Explorations of how specific bioactive metabolites modulate immune cell functions.
-Studies identifying the role of G protein-coupled receptors in mediating the effects of metabolites on the immune system.
-Analysis of metabolic shifts occurring during chronic inflammation and their implications for disease progression.
-Evaluative research on metabolic-targeting drugs and their potential efficacy in clinical settings.
-Comparative analyses between metabolic and immune profiles in cancer versus autoimmune and autoinflammatory conditions.

This focused Research Topic aims to bridge gaps in the current understanding, providing a platform for innovative research that could lead to breakthroughs in therapeutic modalities. By integrating studies from a diverse array of disciplines within immunology and metabolic science, we anticipate fostering a richer comprehension and more effective interventions in the realms of chronic inflammatory diseases.

Are you interested in contributing a manuscript to this Research Topic?

Cell Metabolism and Bioactive Metabolites in Chronic Inflammation