Sepsis, a complex syndrome driven by a dysregulated host response to infection, is closely linked to both metabolic and immune processes that lead to organ dysfunction. Recent studies have highlighted the critical role of immune dysfunction in the progression of sepsis, pointing towards the reversal of this dysfunction as a promising therapeutic strategy. Metabolic reprogramming, a hallmark pathophysiological alteration in sepsis, interplays extensively with immune functionality and patient outcomes. Investigations have shed light on key regulatory pathways that bridge metabolism and immune responses, demonstrating the crucial role of metabolism in modulating immunity. Such interactions include multiple metabolic pathways like fatty acid metabolism, aerobic glycolysis, the tricarboxylic acid cycle, and itaconate metabolism, which can either promote or suppress inflammation, ultimately affecting sepsis outcomes.
The goal of this research topic is to compile a comprehensive overview of current knowledge on metabolism and its interconnection with immune functions in sepsis. We aim to investigate how metabolic pathways contribute to the dysregulation of immune responses and explore potential therapeutic interventions that target these pathways. The focus will also be on developing innovative treatments to modulate these interactions to improve sepsis treatment.
To further our understanding in this critical area, we seek contributions encompassing a variety of study types, including Original Research, Systematic Reviews, Mini-Reviews, Perspectives, and Clinical Trials. Specific themes of interest include, but are not limited to:
• Metabolic reprogramming of immune cells in response to inflammatory signals in sepsis.
• The role of Intermediate metabolites in modulating immune function.
• Metabolic interactions among different immune cells and their impacts on sepsis prognosis.
• Dynamics of metabolic changes across different sepsis states.
• Therapeutic targeting of immunometabolism pathways in the prevention and treatment of sepsis.
Sepsis, a complex syndrome driven by a dysregulated host response to infection, is closely linked to both metabolic and immune processes that lead to organ dysfunction. Recent studies have highlighted the critical role of immune dysfunction in the progression of sepsis, pointing towards the reversal of this dysfunction as a promising therapeutic strategy. Metabolic reprogramming, a hallmark pathophysiological alteration in sepsis, interplays extensively with immune functionality and patient outcomes. Investigations have shed light on key regulatory pathways that bridge metabolism and immune responses, demonstrating the crucial role of metabolism in modulating immunity. Such interactions include multiple metabolic pathways like fatty acid metabolism, aerobic glycolysis, the tricarboxylic acid cycle, and itaconate metabolism, which can either promote or suppress inflammation, ultimately affecting sepsis outcomes.
The goal of this research topic is to compile a comprehensive overview of current knowledge on metabolism and its interconnection with immune functions in sepsis. We aim to investigate how metabolic pathways contribute to the dysregulation of immune responses and explore potential therapeutic interventions that target these pathways. The focus will also be on developing innovative treatments to modulate these interactions to improve sepsis treatment.
To further our understanding in this critical area, we seek contributions encompassing a variety of study types, including Original Research, Systematic Reviews, Mini-Reviews, Perspectives, and Clinical Trials. Specific themes of interest include, but are not limited to:
• Metabolic reprogramming of immune cells in response to inflammatory signals in sepsis.
• The role of Intermediate metabolites in modulating immune function.
• Metabolic interactions among different immune cells and their impacts on sepsis prognosis.
• Dynamics of metabolic changes across different sepsis states.
• Therapeutic targeting of immunometabolism pathways in the prevention and treatment of sepsis.