The cardiovascular-kidney-metabolic syndrome (CKM) represents a complex interplay of obesity, diabetes, chronic kidney disease, and various cardiovascular conditions (including heart failure, atrial fibrillation, coronary artery disease, stroke, and peripheral artery disease), which collectively contribute to systemic dysfunction. This syndrome is underpinned by a range of pathophysiological processes including glucolipotoxicity, insulin resistance, endothelial dysfunction, oxidative stress, chronic inflammatory responses, endoplasmic reticulum stress, and excessive activation of the renin-angiotensin-aldosterone system (RAAS), leading to progressive organ damage and decreased quality of life. Despite the prevalence of this condition, current treatment strategies often fall short, necessitating more effective multidisciplinary approaches to manage and mitigate the severe health impacts associated with CKM.
This Research Topic aims to foster a deeper understanding of comprehensive treatment regimes, pharmacotherapy advances, and outcome prediction methodologies within the CKM spectrum. By highlighting cutting-edge research and innovative management strategies, this topic seeks to improve patient outcomes through synergistic clinical practices and therapeutic interventions.
To further refine the knowledge and treatment of CKM, contributions are solicited on a variety of relevant themes:
o Epidemiological studies detailing the incidence and spread of CKM
o Innovative strategies for slowing CKM progression
o Development and implementation of integrated management models for CKM
o Pharmacological interventions and their health economic impacts.
The cardiovascular-kidney-metabolic syndrome (CKM) represents a complex interplay of obesity, diabetes, chronic kidney disease, and various cardiovascular conditions (including heart failure, atrial fibrillation, coronary artery disease, stroke, and peripheral artery disease), which collectively contribute to systemic dysfunction. This syndrome is underpinned by a range of pathophysiological processes including glucolipotoxicity, insulin resistance, endothelial dysfunction, oxidative stress, chronic inflammatory responses, endoplasmic reticulum stress, and excessive activation of the renin-angiotensin-aldosterone system (RAAS), leading to progressive organ damage and decreased quality of life. Despite the prevalence of this condition, current treatment strategies often fall short, necessitating more effective multidisciplinary approaches to manage and mitigate the severe health impacts associated with CKM.
This Research Topic aims to foster a deeper understanding of comprehensive treatment regimes, pharmacotherapy advances, and outcome prediction methodologies within the CKM spectrum. By highlighting cutting-edge research and innovative management strategies, this topic seeks to improve patient outcomes through synergistic clinical practices and therapeutic interventions.
To further refine the knowledge and treatment of CKM, contributions are solicited on a variety of relevant themes:
o Epidemiological studies detailing the incidence and spread of CKM
o Innovative strategies for slowing CKM progression
o Development and implementation of integrated management models for CKM
o Pharmacological interventions and their health economic impacts.