Research Topic

Inhibitory Receptors and Pathways of Lymphocytes

About this Research Topic

Immune receptor recognition of antigen/MHC complexes is a key event that determines the outcome of lymphocyte activation and largely the fate of immune responses. Co-receptors and costimulatory molecules coordinate with the immune receptors to amplify and transduce the signals initially triggered by at the cell surface, but equally important are the molecular mechanisms that control and terminate activation responses.

A very fine line separates activation-mediated clonal expansion from cell death by apoptosis at all stages of lymphocyte development. The amplitude of stimulation is tuned by the action of modulatory receptors and associated regulatory molecules that keep activation levels within strict limits or that can collectively contribute to the termination of activation upon resolution of the given immune challenge. Acquisition of effector functions is continuously modulated by a variety of receptors and signaling pathways which balance quiescent, activated and exhausted phenotypes as well as cytolytic activity and cytokine production patterns. Inhibitory signaling molecules can function as receptors, effectors of receptors, or signaling regulators that integrate multiple inputs to modulate immune cell activation states.

In this Research Topic, we welcome the submission of Review, Mini-Review, Opinion and General Commentary articles by researchers working on different inhibitory molecules and pathways of T and B lymphocytes and of NK cells. We welcome articles that discuss relevant molecular and cellular experimental systems and also models of disease, including infection, inflammation and cancer. Collectively this Research Topic aims to inform present and future work towards developing therapeutic strategies targeting inhibitory receptors and signaling molecules.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Immune receptor recognition of antigen/MHC complexes is a key event that determines the outcome of lymphocyte activation and largely the fate of immune responses. Co-receptors and costimulatory molecules coordinate with the immune receptors to amplify and transduce the signals initially triggered by at the cell surface, but equally important are the molecular mechanisms that control and terminate activation responses.

A very fine line separates activation-mediated clonal expansion from cell death by apoptosis at all stages of lymphocyte development. The amplitude of stimulation is tuned by the action of modulatory receptors and associated regulatory molecules that keep activation levels within strict limits or that can collectively contribute to the termination of activation upon resolution of the given immune challenge. Acquisition of effector functions is continuously modulated by a variety of receptors and signaling pathways which balance quiescent, activated and exhausted phenotypes as well as cytolytic activity and cytokine production patterns. Inhibitory signaling molecules can function as receptors, effectors of receptors, or signaling regulators that integrate multiple inputs to modulate immune cell activation states.

In this Research Topic, we welcome the submission of Review, Mini-Review, Opinion and General Commentary articles by researchers working on different inhibitory molecules and pathways of T and B lymphocytes and of NK cells. We welcome articles that discuss relevant molecular and cellular experimental systems and also models of disease, including infection, inflammation and cancer. Collectively this Research Topic aims to inform present and future work towards developing therapeutic strategies targeting inhibitory receptors and signaling molecules.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

31 January 2018 Abstract
31 May 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

31 January 2018 Abstract
31 May 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top