The gut microbiota significantly influences human health, actively participating in numerous physiological processes and disease states. Despite this broad recognition, research specifically focusing on gut microbial composition and functionality concerning women's health remains limited. Women are disproportionately affected by specific health conditions such as polycystic ovary syndrome, osteoarthritis, cardiovascular disease, anxiety, various cancers, and complications related to pregnancy and menopause. Emerging evidence suggests that microbiota-mediated interactions may play a crucial role in the development and progression of these conditions. Recent studies, including those using animal models, have demonstrated alterations in gut microbiota profiles and their metabolites in association with these disorders, highlighting the potential for microbiome modulation as a therapeutic approach. However, a comprehensive understanding of microbiota composition, functionality, and mechanisms —particularly as they relate to sex-specific health outcomes—is still incomplete.

This Research Topic aims to address critical knowledge gaps by collating up-to-date evidence on the role of gut microbiota and microbial metabolites in various women-specific health conditions. We seek to clarify the relationships between microbiota dynamics and the pathophysiology of prevalent health issues encountered uniquely or disproportionately by women. Contributions exploring microbiome modulation, such as through dietary approaches, prebiotic and probiotic supplementation, and fecal microbiota transplantation, are also encouraged.

To advance our understanding of the gut microbiota and women’s health, we welcome contributions discussing basic, preclinical (animal model-based), translational and clinical evidence focusing on, but not limited to, the following themes:

o Association between gut microbiota composition and polycystic ovary syndrome and infertility.
o Roles of gut microbial metabolites in menopause-related symptoms and osteoporosis.
o Influence of microbiota on female-specific gastrointestinal and metabolic disorders.
o Identification of microbial biomarkers and signatures for early detection, prognosis and therapeutic targeting of cancers prevalent in women.
o Effectiveness of dietary interventions, probiotics, prebiotics, and fecal microbiota transplantation in managing gynecological and pregnancy-related complications.

We invite submissions in the form of original research articles, clinical trials, case reports, perspective studies, reviews, mini reviews and systematic reviews.

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Gut Microbiota and Women’s Health: Insights from Basic Research to Clinical Applications