Research Topic

Ocular Biomechanics of Normal Aging and Disease

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About this Research Topic

Many vision-threatening conditions and ocular diseases have implicated biomechanics in the pathogenesis. These include glaucoma, lens dislocation, presbyopia, cataract, retinal detachment, vitreous detachment, trauma, and many others. While many of these manifest with advanced age, not all aged individuals ...

Many vision-threatening conditions and ocular diseases have implicated biomechanics in the pathogenesis. These include glaucoma, lens dislocation, presbyopia, cataract, retinal detachment, vitreous detachment, trauma, and many others. While many of these manifest with advanced age, not all aged individuals will experience these problems. Differentiation between normal aging and factors leading to disease is a challenging goal which will lead to novel prevention and treatment strategies.

This Research Topic will include the Proceedings of the World Congress of Biomechanics’ special session of the same name (this approach has been officially endorsed by the WCB organizers). The focus of this Topic is differentiating between normal and pathological aging. A particular emphasis will be placed on identifying risk factors which distinguish age-related biomechanical changes from pathological biomechanical changes. Such factors may include genetic factors, oxidative stress, radiation exposure, ambient conditions, etc. Papers will include experimental and computational biomechanical approaches to addressing these questions. Tissues of interest may include the cornea, sclera, vitreous humor, lamina cribrosa, lens, trabecular meshwork, zonules, ciliary body, retina, choroid, Schlemm’s canal, and ocular membranes such as the lens capsule, Bruch’s membrane, Bowman’s membrane, Descemet’s membrane, hyaloid membrane.

Potential themes for this Topic include:
• Normal aging of the eye and visual system
• Aging, genetics, and environmental causes of vision loss
• Differentiating between multiple causes of vision loss


Keywords: ocular biomechanics, aging, disease, pathological aging, crosslinking


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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