About this Research Topic
Dysbiosis refers to a condition with microbial imbalances within the microbiome. Bioengineering approaches can be used for reshaping the dysbiotic microbiome by specifically targeting individual microbial species in the microbiome. Many antimicrobials including antibiotics without selectivity may destroy the beneficial microbes in the microbiome that helps fight pathogens and maintain homeostasis of microbiome. Probiotics can be applied for suppression of over-growth of pathogens. Probiotics or selective fermentation initiators (SFIs) have been utilized to exclusively amplify the activity of probiotic microbes against pathogens. Phage therapy is yet another manipulation technique, by which selective overgrown microbes can be targeted with specific bacteriophages, thereby normalizing the dysbiotic skin microbiome. Other bioengineering approaches including microbiome editing with CRISPR/Cas9 or engineered microbes hold promise as potential modalities for re-equilibrate the dysbiotic microbiome.
The Research Topic seeks existing and novel bioengineering approaches for microbiome editing.
Keywords: Bioengineering, Dysbiosis, Editing, Microbiome, Probiotics
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