Research Topic

Bioengineering Approaches for Microbiome Editing

About this Research Topic

Dysbiosis refers to a condition with microbial imbalances within the microbiome. Bioengineering approaches can be used for reshaping the dysbiotic microbiome by specifically targeting individual microbial species in the microbiome. Many antimicrobials including antibiotics without selectivity may destroy the beneficial microbes in the microbiome that helps fight pathogens and maintain homeostasis of microbiome. Probiotics can be applied for suppression of over-growth of pathogens. Probiotics or selective fermentation initiators (SFIs) have been utilized to exclusively amplify the activity of probiotic microbes against pathogens. Phage therapy is yet another manipulation technique, by which selective overgrown microbes can be targeted with specific bacteriophages, thereby normalizing the dysbiotic skin microbiome. Other bioengineering approaches including microbiome editing with CRISPR/Cas9 or engineered microbes hold promise as potential modalities for re-equilibrate the dysbiotic microbiome.
The Research Topic seeks existing and novel bioengineering approaches for microbiome editing.


Keywords: Bioengineering, Dysbiosis, Editing, Microbiome, Probiotics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Dysbiosis refers to a condition with microbial imbalances within the microbiome. Bioengineering approaches can be used for reshaping the dysbiotic microbiome by specifically targeting individual microbial species in the microbiome. Many antimicrobials including antibiotics without selectivity may destroy the beneficial microbes in the microbiome that helps fight pathogens and maintain homeostasis of microbiome. Probiotics can be applied for suppression of over-growth of pathogens. Probiotics or selective fermentation initiators (SFIs) have been utilized to exclusively amplify the activity of probiotic microbes against pathogens. Phage therapy is yet another manipulation technique, by which selective overgrown microbes can be targeted with specific bacteriophages, thereby normalizing the dysbiotic skin microbiome. Other bioengineering approaches including microbiome editing with CRISPR/Cas9 or engineered microbes hold promise as potential modalities for re-equilibrate the dysbiotic microbiome.
The Research Topic seeks existing and novel bioengineering approaches for microbiome editing.


Keywords: Bioengineering, Dysbiosis, Editing, Microbiome, Probiotics


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 January 2018 Abstract
01 April 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 January 2018 Abstract
01 April 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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