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Pathogenic microorganisms have a primary goal of exploiting the metabolites of the host cells by manipulating the host metabolism. They can rewire the metabolic interactions of the host with the major objective of sustained survival. Host cells, on the other hand, try to prevent the disruption caused by ...

Pathogenic microorganisms have a primary goal of exploiting the metabolites of the host cells by manipulating the host metabolism. They can rewire the metabolic interactions of the host with the major objective of sustained survival. Host cells, on the other hand, try to prevent the disruption caused by pathogens in their metabolic networks. Thus, several metabolic changes are induced in both pathogen and host sides in the course of infection. Understanding these alterations is crucial to develop novel diagnostics and treatment strategies for infectious diseases.

Therefore, systems biology approach is commonly used to elucidate the effect of infection on cell metabolism and to identify potential biomarkers and drug targets. Therefore, the following themes will be covered in this Research Topic:

- Constraint-based reconstruction and analysis of genome-scale metabolic networks for infection research
- Structure-based and sequence-based analysis of enzymes derived from metabolic pathway comparisons
- Metabolomics and fluxomics in infection research
- Data mining and statistics in infection research to identify metabolism-derived biomarker and drug target candidates

Keywords: Systems Biology, Metabolic Interaction Network, Pathogen-Host Interaction, Constraint-based analysis, Structure-based analysis


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