Research Topic

SIRT1 in Endocrinology

About this Research Topic

SIRT1 is a member of the class III group of histone deacetylases, collectively called sirtuins. SIRT1 deacetylates serine/threonine kinase 11, endothelial nitric oxide synthase (eNOS), and histones H1, H3, and H4. It has been reported that SIRT1 performs a wide variety of functions in a variety of biological systems, including obesity-associated metabolic diseases, endocrine disease, cancer, aging, cellular senescence, oxidative stress, prion-mediated neurodegeneration, inflammation, and placental cell survival. SIRT1 is downregulated in cells that have high insulin resistance and increased levels of SIRT1 is able to increase insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors. Moreover, recent studies have demonstrated that SIRT1 plays a pivotal roles in bone metabolism, cardiovascular diseases, diabetes, cancer, and neurological diseases.

This Research Topic will solicit original research articles, reviews, systematic review and meta analysis, commentaries, etc that cover the themes of diabetes, thyroid diseases, cardiovascular metabolism, cancer endocrinology, bone metabolism.


Keywords: Silent information regulator 1, Metabolism; Endocrinology, Diabetes, Cardiovascular medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

SIRT1 is a member of the class III group of histone deacetylases, collectively called sirtuins. SIRT1 deacetylates serine/threonine kinase 11, endothelial nitric oxide synthase (eNOS), and histones H1, H3, and H4. It has been reported that SIRT1 performs a wide variety of functions in a variety of biological systems, including obesity-associated metabolic diseases, endocrine disease, cancer, aging, cellular senescence, oxidative stress, prion-mediated neurodegeneration, inflammation, and placental cell survival. SIRT1 is downregulated in cells that have high insulin resistance and increased levels of SIRT1 is able to increase insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors. Moreover, recent studies have demonstrated that SIRT1 plays a pivotal roles in bone metabolism, cardiovascular diseases, diabetes, cancer, and neurological diseases.

This Research Topic will solicit original research articles, reviews, systematic review and meta analysis, commentaries, etc that cover the themes of diabetes, thyroid diseases, cardiovascular metabolism, cancer endocrinology, bone metabolism.


Keywords: Silent information regulator 1, Metabolism; Endocrinology, Diabetes, Cardiovascular medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 January 2018 Abstract
31 May 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 January 2018 Abstract
31 May 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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