Sepsis and inflammation-related critical illnesses, like severe acute pancreatitis and acute respiratory distress syndrome (ARDS), are significantly influenced by immune dysregulation and metabolic disorders. Recent studies have illuminated the critical role of aberrant glucose and lipid metabolism in these conditions, emphasizing the impact of excessive glycolysis and lipid handling disorders on organ function. Furthermore, the interconnection between metabolic disturbances and immune dysfunction has emerged as a pivotal focus, suggesting a complex interplay that influences the onset and severity of these illnesses. Despite ongoing research, the intricate mechanisms underlying these relationships remain inadequately understood, necessitating further investigation to fill these gaps and improve patient outcomes.

This Research Topic aims to explore the complex interplay between glucose and lipid metabolism and immune dysfunction in sepsis and inflammation-related critical illnesses. Our primary goal is to dissect the underlying mechanisms that contribute to metabolic derangements and altered hormonal pathways, shedding light on potential therapeutic targets. Through this understanding, we aim to refine clinical management strategies and develop novel interventions that can reduce organ dysfunction and improve survival rates for critically ill patients. By answering key questions and testing pertinent hypotheses, this research endeavors to bridge significant knowledge gaps.

The scope of this topic is centered around understanding metabolic and hormonal dynamics in sepsis and inflammation related critical illnesses. We encourage contributions in the following areas:
o Hormonal pathway alterations focusing on dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis, hypothalamic-pituitary-thyroid (HPT) axis, and the insulin-glucose axis in critical illness.
o Disruptions in glucose and lipid metabolism related to sepsis and inflammation related critical illnesses.
o The crosstalk between metabolic disorders and inflammatory responses.
o Exploration of the role of post-translational modifications (PTM) in these conditions.
o Development of therapeutic strategies based on metabolic and immune interactions.

We welcome original research articles, reviews, and other acceptable article types that contribute to this Research Topic.

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Metabolic Implications in Sepsis and Inflammation-related Critical Illnesses