Given the success of the Research Topic Tumor Microenvironment and Personalized Therapy of Gastrointestinal Cancer and the necessity of this subject area, we are pleased to announce the launch of Volume II.Gastrointestinal cancer is a heterogeneous and aggressive disease. Tumors are constantly evolving entities with continuous interaction between the tumor cells and the diverse environment surrounding them. This microenvironment serves as a reservoir of factors that enable and sustain the characteristics and variability of cancer cells. Consequently, research on gastrointestinal cancer has shifted from solely focusing on tumor cells to encompassing the tumor microenvironment, which includes tumor cells, inflammatory cells, fibroblasts, nerves, vascular endothelial cells, etc. Studies have shown that the interactions among these components can promote tumor progression and influence the efficacy of the therapy. Therefore, gaining a deeper understanding of the microenvironment can unveil the mechanisms driving tumor progression, enable personalized treatment approaches, and facilitate the development of innovative therapy strategies.Meanwhile, advancements in immunotherapy and molecular targeted therapy have expanded the range of comprehensive treatments available for gastrointestinal cancer. However, significant challenges remain, such as identifying patients who would benefit most from these treatments, managing adverse reactions, and overcoming persistent therapy resistance. In the perioperative setting, the survival benefits of immunotherapy have yet to be definitively confirmed. These challenges further underscore the need for further investigation into how the tumor microenvironment contributes to resistance and progression.This Research Topic aims to provide an updated understanding of the gastrointestinal tumor microenvironment, unravel the mechanisms by which the interactions among its components contribute to tumor progression, thereby establish effective predictive methods for assessing the efficacy of immunotherapy and molecular targeted therapy, and seek to develop novel therapeutic strategies considering this knowledge from both clinical and fundamental research perspectives.Researchers are invited to submit their original research, systematic reviews, mini reviews, clinical trials, case reports, and opinions relevant to the collection. The scope of the Research Topic includes but is not limited to:• Analyzing the microenvironment of gastrointestinal tumors and investigating the mechanisms driving tumor progression. • Identifying crucial cell components and biomarkers that contribute to personalized therapy.• Investigating resistance mechanisms and developing therapies to reverse resistance.• Developing predictive models for treatment efficacy and adverse events to better identify potential beneficiaries.• Advancements in new immunotherapy and molecular targeted therapy (with or without chemotherapy).
Given the success of the Research Topic Tumor Microenvironment and Personalized Therapy of Gastrointestinal Cancer and the necessity of this subject area, we are pleased to announce the launch of Volume II.Gastrointestinal cancer is a heterogeneous and aggressive disease. Tumors are constantly evolving entities with continuous interaction between the tumor cells and the diverse environment surrounding them. This microenvironment serves as a reservoir of factors that enable and sustain the characteristics and variability of cancer cells. Consequently, research on gastrointestinal cancer has shifted from solely focusing on tumor cells to encompassing the tumor microenvironment, which includes tumor cells, inflammatory cells, fibroblasts, nerves, vascular endothelial cells, etc. Studies have shown that the interactions among these components can promote tumor progression and influence the efficacy of the therapy. Therefore, gaining a deeper understanding of the microenvironment can unveil the mechanisms driving tumor progression, enable personalized treatment approaches, and facilitate the development of innovative therapy strategies.Meanwhile, advancements in immunotherapy and molecular targeted therapy have expanded the range of comprehensive treatments available for gastrointestinal cancer. However, significant challenges remain, such as identifying patients who would benefit most from these treatments, managing adverse reactions, and overcoming persistent therapy resistance. In the perioperative setting, the survival benefits of immunotherapy have yet to be definitively confirmed. These challenges further underscore the need for further investigation into how the tumor microenvironment contributes to resistance and progression.This Research Topic aims to provide an updated understanding of the gastrointestinal tumor microenvironment, unravel the mechanisms by which the interactions among its components contribute to tumor progression, thereby establish effective predictive methods for assessing the efficacy of immunotherapy and molecular targeted therapy, and seek to develop novel therapeutic strategies considering this knowledge from both clinical and fundamental research perspectives.Researchers are invited to submit their original research, systematic reviews, mini reviews, clinical trials, case reports, and opinions relevant to the collection. The scope of the Research Topic includes but is not limited to:• Analyzing the microenvironment of gastrointestinal tumors and investigating the mechanisms driving tumor progression. • Identifying crucial cell components and biomarkers that contribute to personalized therapy.• Investigating resistance mechanisms and developing therapies to reverse resistance.• Developing predictive models for treatment efficacy and adverse events to better identify potential beneficiaries.• Advancements in new immunotherapy and molecular targeted therapy (with or without chemotherapy).