Advancing the Clinical Application of Natural Killer Cell Therapies

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Articles

ORIGINAL RESEARCH

Published on 01 Jun 2026

Chemical priming potentiates mesothelin-targeting chimeric antigen receptor-engineered NK-92 antitumor activity by improving tumor trafficking and cytotoxic killing dynamics

Ki Seo Ryu
Hail Park
Eunchong Maeng
Jun-Yeon Lim
Duck Cho
Seung Hee Choi
Kyung-Soon Park

doi 10.3389/fimmu.2026.1860442

1,325 views

ORIGINAL RESEARCH

Published on 08 May 2026

Cytokine preactivation and ADCC: a potent strategy for enhancing human NK cell effector functions against 3D tumor models

Ainara Lopez-Pardo
Ainhoa Amarilla-Irusta
Ainhoa Iturbe-Larrondo
Itxaso San Juan
Víctor Sandá
Olatz Zenarruzabeitia
Francesca D Ciccarelli
Francisco Borrego
Laura Amo

doi 10.3389/fimmu.2026.1797290

1,260 views

REVIEW

Published on 20 Mar 2026

The metabolic environment within solid tumors drives a complex crosstalk between macrophages and NK cells

Didem Cakirsoy Akyoney
Joel Nordin
Samir El Andaloussi
Evren Alici

doi 10.3389/fimmu.2026.1726590

1,669 views

REVIEW

Published on 09 Mar 2026

Insights into ectodomain shedding as a novel target in natural killer cell-based immunotherapy for cancer

Ruan Pimenta
Jun Arai
Luiza Ribeiro de Lima Brandao
Pascale Schmidt
Bruna Taciane da Silva Bortoleti
Lucas Ferrari de Andrade

doi 10.3389/fimmu.2026.1753470

1,736 views

ORIGINAL RESEARCH

Published on 12 Feb 2026

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases

Sookyung Hwang
Paul D. David Bates
Vasiliki Valkanioti
Chih-Chun Chang
Sandro Mecozzi
Christian M. M Capitini

doi 10.3389/fimmu.2026.1772375

1,229 views

ORIGINAL RESEARCH

Published on 30 Jan 2026

Dual-functioning Targeted ADAM17 Blocker CD16 (TAB16) mediates selective ADAM17 inhibition in NK cells and engages overexpressed ADAM17 in tumor cells to induce cytotoxicity

Kate J. Dixon
Robert Hullsiek
Sam Wang
Ryan R. Friess
Anders W. Matson
Yvette Soignier
Alexander J. Lenvik
Jianming Wu
Geoffrey T. Thomas Hart
1 more
Bruce Walcheck

doi 10.3389/fimmu.2026.1714022

2,036 views
2 citations

REVIEW

Published on 19 Jan 2026

Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application

Tianyuan Ren
Fengjiang Wang
Xuan Liu
Jun Guo
Sitan Xie

doi 10.3389/fonc.2025.1759796

4,669 views
3 citations

REVIEW

Accepted on 15 Jul 2026

Natural Killer Cells at the Interface of Tumor Immune Escape and Immunotherapy Resistance in Endometrial Cancer

Valentina Bruno
Anna Di Spirito
Alessandro Poggi
Lorenzo Mortara
Denisa Baci

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Frontiers in Immunology

Cancer Immunity and Immunotherapy
NK and Innate Lymphoid Cell Biology

Other participating journals

Frontiers in Oncology
- Cancer Immunity and Immunotherapy
- 3.4 impact factor
- 6.6 citescore

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Articles

Chemical priming potentiates mesothelin-targeting chimeric antigen receptor-engineered NK-92 antitumor activity by improving tumor trafficking and cytotoxic killing dynamics

Cytokine preactivation and ADCC: a potent strategy for enhancing human NK cell effector functions against 3D tumor models

The metabolic environment within solid tumors drives a complex crosstalk between macrophages and NK cells

Insights into ectodomain shedding as a novel target in natural killer cell-based immunotherapy for cancer

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases

Dual-functioning Targeted ADAM17 Blocker CD16 (TAB16) mediates selective ADAM17 inhibition in NK cells and engages overexpressed ADAM17 in tumor cells to induce cytotoxicity

Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application

Natural Killer Cells at the Interface of Tumor Immune Escape and Immunotherapy Resistance in Endometrial Cancer

Frontiers in Immunology

Cancer Immunity and Immunotherapy

NK and Innate Lymphoid Cell Biology

Other participating journals

Frontiers in Oncology

Cancer Immunity and Immunotherapy