The field of trained immunity is emerging as a promising area of research, with significant interest in how non-specific immune training can be exploited to improve health outcomes. This collection focuses on probiotics and beta-glucans, two agents that show potential in modulating the immune system through immunostimulation and trained immunity. Probiotics and beta-glucans have garnered attention for their roles in enhancing immune responses and providing protection against infections and chronic diseases. By a better understanding of the molecular mechanisms through which these agents stimulate innate immune cells and promote immunological memory, researchers aim to uncover novel strategies for boosting overall health and preventing a variety of immunological disorders.

Understanding these mechanisms involves exploring their ability to enhance the function of innate immune cells, such as macrophages and dendritic cells, which traditionally serve as the first line of defense against pathogens. By influencing these cells, probiotics and beta-glucans can establish a state of 'trained immunity,' where the innate immune system exhibits improved readiness and functionality upon subsequent challenges.

This research topic seeks to publish high-quality reviews and original research articles exploring the role of probiotics and beta-glucans in immune modulation through the lens of immunostimulation and trained immunity. The primary goal is to establish this collection as a leading resource in this dynamic and potentially transformative field of human health and disease.

Researchers are encouraged to submit articles addressing, but not limited to, the following themes:

-The molecular pathways involved in the trained immunity response triggered by probiotics and beta-glucans.
-Clinical applications showcasing the use of these agents in preventing or treating infectious and chronic inflammatory diseases.
-Strategies to improve the therapeutic outcomes of probiotics and beta-glucans in immunomodulation.
-Preclinical and clinical studies that evaluate the efficacy of these agents in enhancing immunological memory and overall immune resilience.
-Mechanistic insights into how probiotics and beta-glucans modulate the gut microbiota and its effect on systemic immunity.
-The role of diet and lifestyle factors in influencing the efficacy of probiotics and beta-glucans in trained immunity.
-Comparative studies on the immunomodulatory effects of different strains of probiotics and types of beta-glucans.
-Investigations into the long-term safety and side effects of probiotics and beta-glucans as part of immune intervention strategies.

This collection could become a key resource for immunologists, clinicians, and researchers interested in innovative approaches to immune modulation, immunostimulation, and the therapeutic potential of trained immunity.

The topic editors declare no conflicts of interest

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Harnessing the Power of Trained Immunity: Probiotics and Beta-Glucans in Immune Modulation