Research Topic

Reorganization, Remodelling and Compensatory Brain Changes in Psychiatric Disorders

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About this Research Topic

Structural, functional and neurochemical brain changes in neuropsychiatric disorders, are most often taken to represent primary mechanistic processes that result in symptoms and dysfunction. But in recent times, several lines of evidence suggest that in both childhood-onset and adult-onset disorders (e.g. ...

Structural, functional and neurochemical brain changes in neuropsychiatric disorders, are most often taken to represent primary mechanistic processes that result in symptoms and dysfunction. But in recent times, several lines of evidence suggest that in both childhood-onset and adult-onset disorders (e.g. autism, ADHD, psychosis, mood disorders, traumatic brain injury and PTSD) the observed neurobiological changes could also be a result of compensatory efforts or remodelling in response to the physiological or behavioural abnormalities resulting from these disorders. We need to improve our understanding of these processes in order to build more precise models of risk, resilience and recovery in psychiatric disorders. As these nuanced interpretations emerge, it is being increasingly recognized that methodological improvements in neuroimaging will greatly enhance our ability to move forwards. For example, longitudinal imaging, multimodal imaging, interventional ‘perturb and measure’ imaging using pharmacological, psychological or neuromodulatory manipulations and the study of non-pathological groups along the illness spectrum, are some of the possible designs that can aid in our progress in this area.

This Research Topic intends to update the readers on both the theoretical approaches and empirical observations supporting the process of cerebral reorganization in psychiatric disorders. Manuscripts will focus on highlighting the role for remodelling and compensation in psychiatric disorders. In particular, evidence for relationship between recovery or remission and compensatory changes will be presented using various techniques such as morphometry, diffusion imaging, resting state or task-based functional imaging, electro or magnetoencephalography, neurochemical imaging using spectroscopy or positron emission tomography and other quantitative imaging approaches. A particular emphasis will be placed on treatment-induced brain changes that speak to the neuroplasticity processes observed in large-scale brain systems.

Researchers are welcome to submit original data from studies using various neuroimaging techniques in clinical and preclinical settings and investigating different psychiatric disorders. We also encourage submission of thought-provoking review papers and recommendations for future research.


Keywords: Risk, Resilience, Compensation, Reorganisation, Remodelling


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