Unveiling the interplay between epigenetics, metabolism, and cancer immunity

The field of cancer research is increasingly exploring the intricate intersections among epigenetics, cancer metabolism, and immunotherapy. These intersecting domains offer immense potential for advancing cancer treatment and patient outcomes. Epigenetic modifications, which regulate gene expression without altering the DNA sequence itself, are capable of rewiring cancer metabolism and have shown significant promise in influencing the tumor microenvironment and enhancing immune responses. Metabolic reprogramming in cancer cells is crucial for their growth and survival, while various metabolites can also affect how immune cells recognize and attack tumors, evoking the concept of immunometabolism in the context of immunotherapy. Understanding the dynamic crosstalk between these biological processes is fundamental to developing innovative and more effective therapeutic strategies.

This Research Topic seeks to unravel the complex relationships among these three areas. Specifically, it aims to answer critical questions such as how epigenetic therapies can increase the effectiveness of immunotherapies, how changes in cancer metabolism impact immune function, and how these two processes influence one another reciprocally. By examining these interactions, the Research Topic aims to uncover novel approaches to overcoming therapy resistance and improving cancer treatment efficacy.

This Research Topic encompasses a diverse range of studies and themes. While broad in scope, it focuses on the interconnections between these fields:

• Epigenetics' role in enhancing cancer immunotherapy
• Identification of metabolic pathways' influence on immune cell function
• Investigating the interactions between cancer metabolism and immune responses
• Reciprocal regulation between epigenetic changes and metabolic reprogramming across cancer cell types
• Development of combined therapeutic strategies employing insights from these intersections

We invite original research articles, reviews, and perspectives that contribute to these themes and expand our understanding of the crosstalk between epigenetics, cancer metabolism, and immunotherapy. By contributing to this comprehensive overview, researchers can pave the way for more integrated and targeted cancer therapies.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Epigenetics, Cancer metabolism, Immunotherapy, Tumor microenvironment, Metabolic reprogramming, Immunometabolism, Therapy resistance, Combined therapeutic strategies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.