About this Research Topic
Nanomaterials-based drug delivery system has been seen as the publicly known strategy to improve the therapeutic efficacy in cancer therapies. However, dense extracellular matrix and interstitial fluid pressure in the tumor suppress the deep delivery and lead to inhomogeneous treatments. Not only to accumulate at highly permeable peripheral blood vessels by enhanced permeability and retention (EPR) effect, the nanohybrids should be also concerned with different functions to enhance the drug delivery. Stimuli-response and functions of nanohybrids are two impressive manipulations for enhanced drug delivery. Besides, targeting moiety for specific diseases also shelters the
mononuclear phagocyte system and promotes the enhanced delivery.
Therefore, after the drug injection, the obstacles from blood circulation, tumor accumulation, to penetrated delivery should be considered comprehensively, and thus multifunctional nanohybrids will be the ideal platforms for enhanced drug delivery. The development of new nanohybrids represents an important orientation in the field of drug delivery systems. Furthermore, the short/mid/long term potential of these materials, taking into account the regulatory issues in humans, is also important in the future.
This Research Topic (Frontiers Special Issue) has the aim of highlighting current progress in the use of the multifunctional nanohybrids for enhanced drug delivery.
Keywords: Drug delivery, Controlled release, Nanomedicine, Functional materials, Composites
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