The year 2025 has been a landmark period for liver transplantation, marked by vibrant scientific discourse and significant advancements that continue to shape the field. In recognition of the groundbreaking research, critical insights, and evolving paradigms emerging across the global community, we invite transplantation researchers, clinicians, and scientists to contribute to this Research Topic: “Reflections on Liver Transplantation: Emerging Research and Clinical Perspectives in 2025.”
This collection offers a unique opportunity to delve into, expand upon, and critically analyze the most prominent themes, cutting-edge research, and evolving paradigms in liver transplantation. We encourage submissions that explore the most impactful advancements, highlight emerging challenges, and offer insightful perspectives that will drive progress and shape the future of the field.
Given the broad and dynamic nature of contemporary liver transplantation research, this Research Topic is intentionally wide in scope and encompasses a diverse spectrum of subjects. We welcome original research articles, comprehensive reviews, compelling perspectives, and insightful commentaries across, but not limited to, the following key areas:
Clinical Innovations: Advances in surgical techniques, pre- and post-transplant recipient and donor management, immunosuppression strategies, and long-term outcomes.
Basic and Translational Science: Breakthroughs in immunology, virology, oncology, regenerative medicine, and genetic research relevant to liver transplantation.
Patient-Centered Care: Addressing quality of life, psychosocial aspects, ethical considerations, adherence, and the management of long-term complications in transplant recipients.
Technological and Digital Health: Applications of artificial intelligence (AI), machine learning, big data, telehealth, advanced imaging, and novel diagnostics in transplantation.
Global Health and Policy: Disparities in access to care, organ allocation systems, policy implications, and challenges in low-resource settings.
Emerging Therapies: Novel pharmacological agents, cellular therapies, ex-vivo organ perfusion techniques, and alternative therapeutic strategies.
Specific Liver Diseases: Management of hepatocellular carcinoma (HCC), acute liver failure, metabolic diseases, viral hepatitis, and other specific etiologies in the transplant setting.
Transplant Immunology: Mechanisms of rejection, tolerance induction, and the role of the microbiome in transplant outcomes.
We seek contributions that not only reflect on the critical discussions shaping the field but also extend their implications, present new data, propose future directions, or offer novel interpretations. This is an opportunity to contribute to a dynamic collection that captures the pulse of current liver transplantation research and helps chart its future course. Join us in this essential reflection and contribute to the collective knowledge that continuously advances our ability to save and improve lives worldwide.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Community Case Study
Curriculum, Instruction, and Pedagogy
Data Report
Editorial
FAIR² Data
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Community Case Study
Curriculum, Instruction, and Pedagogy
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Policy and Practice Reviews
Policy Brief
Review
Study Protocol
Systematic Review
Technology and Code
Keywords: ILTS, Liver Transplant, Transplant Immunology, Organs, Patient-Centered Care
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
