About this Research Topic
Natural products continue to be an indispensable source of leads for new medicines in order to fulfill the burgeoning market demand. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread emergence of antimicrobial-resistant pathogens, and coinciding with the reduced number of new drugs in the market, have driven this field of research further by looking at all potential sources of natural products. The concept of drug discovery from microbial sources have made significant contributions to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers and highly pertinent in face of today’s booming resistance and health issues.
Actinobacteria are one of the most prominent and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds. In fact, they have provided more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Further in depth studies have then evidenced the molecular targets and mechanisms through modulation of cellular pathways mediated by the Actinobacteria-derived bioactive compounds in eliciting those bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources.
With the recent success of the Research Topic- The search for biological active agent(s) from actinobacteria, we have evidenced a great leap in number and quality research focusing on the interesting compounds produced by Actinobacteria along with promising bioactivities. In current Research Topic, we aimed to provide a platform for discussion of broader range of biological potentials possessed by actinobacteria followed by the further in depth studies. In light of these current needs, and great interest in the scope of this research, this Research Topic seeks contributions on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer and other activities.
Keywords: actinobacteria, bioactive metabolites, natural product, antimicrobial, antioxidant, neuroprotection, anticancer
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