Research Topic

Gut Microbiota as a New Therapeutic Target for Central Nervous System Diseases

  • Submission closed.

About this Research Topic

The development of the Central Nervous System (CNS) is an intricate process that is governed by both intrinsic and extrinsic factors in humans. The human’s microbiome consists of unique assemblages of microorganisms (e.g. bacteria, archaea, fungi, and viruses), that shape the host’s immune, physiology, behavior, and neuropathology. In recent years, accumulating clinical and experimental evidence suggests that gut microbiota play an essential role in CNS diseases including anxiety, depression, neurodegenerative, and autism spectrum disorder (ASD). The influences of the microbiome on CNS functions can be achieved through a microbiota-gut-brain axis that is connected via neural, endocrine, metabolic and immunological pathways, respectively. Therefore, the plastic nature of the human microbiome makes it a new therapeutic target for CNS diseases, and many factors (e.g. probiotics, antibiotics, diet and drug) were easy to alter the composition of the gut microflora.

In the treatment of other diseases, gut microbiota serves as therapeutic target through changing its metabolism or composition. For example, gut microbiota is one of the factors that could cause berberine to ameliorate hyperlipidemia, and metformin to treat type 2 diabetes. Therefore, gut microbiota might be the potential target for drugs to treat CNS diseases.

In the present Research Topic, we welcome researchers to submit original research articles reporting data from both animal experimental and clinical studies, and review articles that help understanding the mechanism of communication between gut microbiota and CNS. We believe that this Research Topic will give further insights in the treatment of CNS diseases, which may develop a new therapeutic agent to improve human health.


Keywords: Gut microbiota, Central Nervous System Diseases, Microbiome–gut–brain axis, Therapy, Target, CNS, Microbiome


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The development of the Central Nervous System (CNS) is an intricate process that is governed by both intrinsic and extrinsic factors in humans. The human’s microbiome consists of unique assemblages of microorganisms (e.g. bacteria, archaea, fungi, and viruses), that shape the host’s immune, physiology, behavior, and neuropathology. In recent years, accumulating clinical and experimental evidence suggests that gut microbiota play an essential role in CNS diseases including anxiety, depression, neurodegenerative, and autism spectrum disorder (ASD). The influences of the microbiome on CNS functions can be achieved through a microbiota-gut-brain axis that is connected via neural, endocrine, metabolic and immunological pathways, respectively. Therefore, the plastic nature of the human microbiome makes it a new therapeutic target for CNS diseases, and many factors (e.g. probiotics, antibiotics, diet and drug) were easy to alter the composition of the gut microflora.

In the treatment of other diseases, gut microbiota serves as therapeutic target through changing its metabolism or composition. For example, gut microbiota is one of the factors that could cause berberine to ameliorate hyperlipidemia, and metformin to treat type 2 diabetes. Therefore, gut microbiota might be the potential target for drugs to treat CNS diseases.

In the present Research Topic, we welcome researchers to submit original research articles reporting data from both animal experimental and clinical studies, and review articles that help understanding the mechanism of communication between gut microbiota and CNS. We believe that this Research Topic will give further insights in the treatment of CNS diseases, which may develop a new therapeutic agent to improve human health.


Keywords: Gut microbiota, Central Nervous System Diseases, Microbiome–gut–brain axis, Therapy, Target, CNS, Microbiome


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);