The management of calcified coronary artery disease poses one of the most formidable challenges in interventional cardiology. Severe coronary calcification can complicate percutaneous coronary interventions (PCI) by hindering device delivery, compromising stent expansion, and increasing the likelihood of adverse outcomes. However, the evolution of advanced imaging modalities, strategic lesion preparation techniques, and novel interventional devices has substantially transformed the treatment landscape for these complex lesions.

This Research Topic in Frontiers in Cardiovascular Medicine aims to offer a comprehensive and multidisciplinary perspective on the current and emerging approaches in treating calcified coronary arteries. We invite submissions of original research, clinical studies, systematic reviews, meta-analyses, technical reports, illustrative case series, and expert perspectives that encompass the entire pathway—from the visualization and characterization of calcified plaques to optimal lesion preparation and advanced device therapy.

Key areas of interest include, but are not limited to:

- Advanced Imaging and Calcium Characterization: The role of intravascular ultrasound (IVUS), optical coherence tomography (OCT), and coronary CT angiography in assessing calcific burden, informing treatment strategies, and guiding interventions.

- Lesion Preparation Techniques: Innovations in high-pressure balloon angioplasty, scoring/cutting balloons, balloon lithotripsy, rotational and orbital atherectomy, laser atherectomy, and evaluating their comparative effectiveness.

- Stenting Strategies: Approaches to optimize stent selection, deployment, and outcomes in severely calcified lesions, including the use of new-generation drug-eluting stents.

Drug-Coated Balloon (DCB) Use: The expanding role of DCBs in managing calcified lesions and their efficacy compared to conventional techniques.

- Clinical Outcomes, Challenges, and Complications: Insights into acute and long-term outcomes, complication management, and strategies to enhance safety and success rates.

The overarching goal is to drive innovation, evidence-based practice, and team-based expertise in the management of calcified coronary disease, ultimately enhancing procedural safety and patient outcomes.

Appendix: We accept submissions of all article types.

Are you interested in contributing a manuscript to this Research Topic?

Advanced Strategies for Calcified Coronary Artery Interventions: From imaging, lesion preparation and innovative therapies