Research Topic

Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches

About this Research Topic

Oxidative stress is one of the main hallmarks of different pathologies processes. Oxidative stress can damage important cell components, including proteins, nucleic acids, lipids and membranes, leading to a dysfunction of homeostasis and normal cell functioning. In order to prevent the increase of free ...

Oxidative stress is one of the main hallmarks of different pathologies processes. Oxidative stress can damage important cell components, including proteins, nucleic acids, lipids and membranes, leading to a dysfunction of homeostasis and normal cell functioning. In order to prevent the increase of free radicals, cells have developed a large range of defense mechanisms. The transcription factor Nrf2 (nuclear factor erythroid 2–related factor 2) is a master regulator of cellular resistance to oxidants and inflammation due to regulation of transcription and expression of inducible antioxidant elements (phase II antioxidant enzymes, reductases, drug transporters, among others) in response to oxidative damage. These proteins are able to scavenge free radicals directly or indirectly, and finally reduce the burden of cellular oxidative stress. A number of studies have focused in the protective mechanisms mediated by Nrf2 and it have been described novel compounds targeting Nrf2. Nrf2 activation protects against oxidative damage produced by inflammation as a result of acute injuries, drugs, exogenous agents and many other stimuli. Therefore, there is a growing interest in the relation between Nrf2 and disease and the identification of novel approaches targeting Nrf2 pathway to prevent and/or retard tissue injury. There are several on-going clinical trials assessing Nrf2-based therapies for the treatment cardiovascular, neurological and renal diseases, among others.


Keywords: Nrf2, oxidation, inflammation, disease, injury


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

24 August 2018 Manuscript
21 December 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

24 August 2018 Manuscript
21 December 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);