Following the success of the initial collection, we are pleased to present a second volume of the Research Topic, “Endocrine Insights into Heart Disease.”
It is increasingly recognized that apart from genetic dispositions affecting the sarcomere or myocardial ability to generate energy, cardiac abnormalities often develop on grounds of primary extracardiac dysfunction. In addition to the most common examples, such as coronary heart disease, hypertension, and diabetes, myocardial involvement is well-documented in, for instance, patients with liver, kidney, and classical endocrine diseases. A caveat is that the majority of evidence accumulated to date comes from clinical observations, and hence is associational by nature. Although it stands to reason that in the mammalian organism, dysfunction at one site may affect another through perturbed homeostasis, our understanding of the modes of how such extracardiac-cardiac cross-talks may occur is still in its infancy. Mechanistic data that identifies functionally relevant abnormalities in the jungle of bystanders is clearly lacking.
Identifying key nodes is important not only out of academic curiosity for increased mechanistic understanding, but also for opportunities to discover novel diagnostic and therapeutic targets. Therefore, as a first step, our aim is to facilitate the generation of novel mechanistic insights into cardiac disease, where extracardiac changes are tied to the heart’s functional integrity. To fill in this gap, we invite original experimental and translational contributions that help explain the development of cardiac dysfunction in any recognized extracardiac condition. In particular, we welcome studies that identify endocrine mechanisms in cardiac conditions reflecting the increase in the prevalence of states with a major unmet medical need (natural ageing, obesity, diabetes, etc.) or identifying critical gender-dependent differences in the development of a cardiac phenotype induced by the same stimuli.
To achieve these aims, we invite experimental studies addressing endocrine mechanisms that impact any form of cardiac dysfunction. The term “endocrine” is used in a broad sense, covering any circulating and humoral factors (proteins, peptides, lipids, or other metabolites). We welcome original contributions where the heart is impacted by circulating factors (i.e., with a significant endocrine component to the development or prevention of cardiac disease).
We welcome papers focusing on, but not limited to:
- Ischemic heart disease - Pressure-overload–induced cardiac hypertrophy - Endocrine inputs to atrial fibrillation - Obesity - Diabetes - Obstructive sleep apnoea - Cardiorenal and cardiohepatic syndromes - Gut microbiota - Exercise - Natural ageing - Sexual dimorphism - Sex Differences in Mitochondrial Bioenergetics and Oxidative Stress - Sex-specific and hormone-dependent cardiac phenotypes - Sex differences in Cardiovascular Remodeling and Heart Failure
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Clinical Trial
Editorial
FAIR² Data
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Hypothesis and Theory
Methods
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Original Research
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
