About this Research Topic
Recent studies on the subject of cell death are challenging previous knowledge of its pathways, effects, and the potential for therapeutic targeting. For example, necroptosis and autophagy and their overlap in survival and drug resistance have only recently begun to be understood. The potential for therapeutic harnessing of other cell death mechanisms such as methuosis, ferroptosis and one we discovered and recently patented – methuophagy – remains unknown.
The interplay between different forms of cell death have significant implications for the study of cancer and potential treatments, in particular for the toxicity and side-effects of newer anticancer agents, gearing us towards more effective therapeutics in future.
This Research Topic on "Death mechanisms, and toxicity" will be devoted to scientific excellence in the field of cancer cell death and survival mechanisms. The most relevant topics will be cell death mechanisms (such as apoptosis) non-apoptotic cell death mechanisms (including but not limited to autophagy, necroptosis, ferroptosis, methuosis) and their interplay in toxicity and survival. Additional relevant topics will include cell and molecular biology, systems level interventions, and mechanisms leading to cell death or survival, proliferation, resistance and metastasis. Predictive toxicology studies in cancer will also be considered for this special issue. We welcome high quality, original papers relating to these subjects, together with solicited and unsolicited reviews, editorial correspondence and commentaries on scientifically informative issues.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.