Micronutrients and Metabolic Diseases-Volume III

Micronutrients, such as vitamins, minerals, and phytochemicals, are involved in diverse metabolic processes, and play critical roles in the maintenance of the normal function of the cardiovascular system, digestive system, immune system, erythropoiesis, and bone health. An imbalanced intake of micronutrients will exert an adverse impact on human health and may give rise to metabolic syndrome (MetS) and metabolic diseases including but not limited to cardiovascular diseases, type 2 diabetes, and neurodegenerative diseases.

Healthy dietary patterns are rich in phytochemicals, antioxidant vitamins, minerals and unsaturated fatty acids that may improve cardiometabolic health and have been recommended as preventive or treatment approaches for cardiovascular diseases and type 2 diabetes. Moreover, supplementation of certain micronutrients (e.g., folic acid, vitamin D, etc.) in populations at risk has been proven to be a highly cost-effective intervention approach for management of metabolic diseases.

However, the role of many micronutrients in metabolic diseases and the underlying regulatory mechanisms remains unclear. Therefore, more study is still needed to: 1) elucidate the relationship between specific micronutrients and distinct metabolic disorders; 2) evaluate the long-term health impacts of chronic micronutrient imbalance across the life course; and 3) delineate the molecular, physiological, and toxicological pathways governing the mechanisms of micronutrient metabolism and its interaction with metabolic homeostasis.

The current research topic, “micronutrients and metabolic diseases” aims to advance current understanding of the roles of micronutrients in metabolic health by integrating epidemiological evidence and mechanistic insights into micronutrient metabolism. This collection seeks to elucidate how micronutrients status influences the development and progression of metabolic diseases and to inform evidence-based strategies for improving dietary patterns and public health.
We welcome high-quality submissions addressing, but not limited to, the following areas:

• Observational studies/interventional studies/interventional trials/pilot studies on micronutrient intake, status, or deficiency and the risk, incidence, progression, or survival of metabolic disorders (MetS or metabolic diseases);

• Experimental and functional studies providing mechanistic insight into micronutrient metabolism with relevance to metabolic regulation and human health;

• Systematic reviews and meta-analysis articles on micronutrients and MetS or metabolic diseases, identifying knowledge gaps, and proposing future research directions.

In the first and second volume of the Research Topic “Micronutrients and metabolic diseases”, 36 articles were published in total, encompassing epidemiological and mechanistic studies investigating the roles of micronutrients in a broad range of human diseases. The third volume of the Research Topic “Micronutrients and metabolic diseases” will place greater emphasis on the link between micronutrient metabolism and cardiometabolic disorders and related diseases. While this third volume will prioritize cardiometabolic outcomes, we will continue to consider high-quality submissions on micronutrients and other metabolic diseases within the broader scope of the Research Topic. We welcome observational/interventional trials/mechanistic studies or comprehensive reviews discussing the cardiometabolic health impact of vitamins, minerals, or phytochemicals.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Registered Report
• Review
• Systematic Review
• Technology and Code

Keywords: micronutrient, trace element, MetS, metabolic disease, cardiovascular disease, diabetes, bone metabolism

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.