Community series in decoding tumor plasticity: integrative analysis of epigenetic regulation and microenvironmental adaptation: Vol. II

This Research Topic is the second volume of the “Decoding Tumor Plasticity: Integrative Analysis of Epigenetic Regulation and Microenvironmental Adaptation ” Community Series. Please see Volume I here


Tumor plasticity presents a profound challenge in the field of oncology, signifying the extraordinary ability of cancer cells to alter their phenotype in adaptation to the ever-changing microenvironment. This adaptability is a key contributor to tumor heterogeneity, therapeutic resistance, and the acceleration of malignant progression. Recent studies indicate that the differentiation pathway of cancer cells is not a unidirectional decline towards a less mature state; rather, it encompasses a complex array of differentiation stages. Results from a confluence of factors, including epigenetic alterations and dynamic responses to the tumor microenvironment, lead to a spectrum of cellular phenotypes within the tumor. The significant function of epigenetic regulation in directing these changes is becoming clear, acting as a critical link between genetic predisposition and environmental influences. Despite these advancements, the intricate molecular mechanisms governing tumor plasticity remain inadequately understood, necessitating further exploration to develop effective therapeutic strategies.


This research topic aims to conduct an in-depth investigation into the intricacies of tumor plasticity and transdifferentiation. We are particularly interested in the delicate interplay between epigenetic master regulators, cell fate determination, and the tumor microenvironment's role. Unraveling this complex molecular story is vital not just for the advancement of innovative cancer therapies but also for achieving a profound understanding of the sophisticated interplay underlying tumor malignancy. By addressing these aspects, the research seeks to answer critical questions about how these factors contribute to cancer progression and resistance, ultimately paving the way for novel therapeutic interventions.


To gather further insights into the dynamics of tumor plasticity, we welcome articles addressing, but not limited to, the following themes:

- Cell Fate and Plasticity: Exploring the role of cell fate decisions in the context of tumor heterogeneity and plasticity.

- Epigenetic Mechanisms: Delving into how epigenetic changes, driven by master regulator networks, facilitate tumor plasticity and transdifferentiation.

- Tumor Microenvironment Contribution: Examining the influence of the tumor microenvironment in modulating tumor plasticity and impacting cancer progression.

- Therapeutic Implications: Discussing the potential of targeting these processes for innovative cancer treatments, with a focus on overcoming resistance.


Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.