Research Topic

Green Synthesis of Heterocycles

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About this Research Topic

Heterocycles are among the most common scaffolds in many organic molecules, e.g., vitamins, hormones, antibiotics, alkaloids, herbicides, dyes, drugs, and pharmaceutically relevant substances. These molecules are also incorporated in numerous macromolecules such as DNA, polymers, and macrocycles, where their hetero-functional units are often employed to establish supramolecular interaction.

It is thus not surprising that—since the 19th century—the synthesis of heterocycles has been constantly blooming, evolving from classic condensation reactions to the development of click reactions and new multicomponent domino synthetic approaches. In the last thirty years, with the ever-growing research developments of new and atom-efficient sustainable synthetic strategies, the field of Green Chemistry has made significant contributions to the development of heterocyclic motifs. The novel methodologies aim at high process performances by means of eco-compatible methodologies, employing non-toxic and biodegradable chemicals.

The goal of this Research Topic is to address some aspects of the numerous advances in the construction of heterocyclic scaffolds via environment-friendly approaches. Discussions of industrial applications, process developments, and future perspectives are also welcome.

As such, the articles included in this Research Topic on the green synthesis of heterocycles will include the following cutting-edge themes:

 • heterocycles from renewable resources
 • preparation via heterogenous metal-free catalytic system easy recyclable
 • waste minimization approach
 • heterocycles via CO2 chemistry
 • synthetic methodologies employing green solvent or solventless approaches
 • Preparation involving Microwave, ultrasound and flow chemistry technology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Heterocycles are among the most common scaffolds in many organic molecules, e.g., vitamins, hormones, antibiotics, alkaloids, herbicides, dyes, drugs, and pharmaceutically relevant substances. These molecules are also incorporated in numerous macromolecules such as DNA, polymers, and macrocycles, where their hetero-functional units are often employed to establish supramolecular interaction.

It is thus not surprising that—since the 19th century—the synthesis of heterocycles has been constantly blooming, evolving from classic condensation reactions to the development of click reactions and new multicomponent domino synthetic approaches. In the last thirty years, with the ever-growing research developments of new and atom-efficient sustainable synthetic strategies, the field of Green Chemistry has made significant contributions to the development of heterocyclic motifs. The novel methodologies aim at high process performances by means of eco-compatible methodologies, employing non-toxic and biodegradable chemicals.

The goal of this Research Topic is to address some aspects of the numerous advances in the construction of heterocyclic scaffolds via environment-friendly approaches. Discussions of industrial applications, process developments, and future perspectives are also welcome.

As such, the articles included in this Research Topic on the green synthesis of heterocycles will include the following cutting-edge themes:

 • heterocycles from renewable resources
 • preparation via heterogenous metal-free catalytic system easy recyclable
 • waste minimization approach
 • heterocycles via CO2 chemistry
 • synthetic methodologies employing green solvent or solventless approaches
 • Preparation involving Microwave, ultrasound and flow chemistry technology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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