Research Topic

Nephrotic Syndrome: Etiology, Genetic Testing, and Biomarkers

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Nephrotic syndrome is the most common form of kidney disease in children and presents with massive leak of serum proteins into the urine resulting in low serum albumin levels, edema, severe hypercholesterolemia, hypertension, increased risk of infection, thrombosis, and kidney failure. Nephrotic syndrome ...

Nephrotic syndrome is the most common form of kidney disease in children and presents with massive leak of serum proteins into the urine resulting in low serum albumin levels, edema, severe hypercholesterolemia, hypertension, increased risk of infection, thrombosis, and kidney failure. Nephrotic syndrome imposes tremendous psychological and social burden on patients and their families. Current therapeutic options display variable and unsatisfactory efficacy influenced by heterogeneous etiology of the syndrome as well as medication costs and side effects.

The International Study of Kidney Disease in Children (ISKDC) established management of pediatric nephrotic in the 1970s. Over the years, the phenotypic presentation of nephrotic syndrome has been changing and the severity has been increasing in some geographic areas and ethnic groups. In spite of this, management strategies of nephrotic syndrome have changed very little during the same time. There have been numerous advances related to the etiology, novel mutations, diagnostic tools, disease biomarkers, treatments, as well as innovative monitoring strategies of nephrotic syndrome. This research topic will focus on the characteristics of nephrotic syndrome across different geographic locations and the recent advances in the management of nephrotic syndrome.


Keywords: Nephrotic syndrome, Podocytes, biomarkers, FSGS, lipid pheresis


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