Dysbiosis in inflammation and immunological diseases

The intricate symbiotic relationship between a host and its microbiota, comprising bacteria, archaea, fungi, and viruses, is fundamental to immunological homeostasis. When this delicate balance is disrupted, a state of dysbiosis occurs, characterized by a marked loss of microbial diversity and a depletion of vital metabolites, such as short-chain fatty acids (SCFAs). Unlike eubiosis, which fosters a harmonious and mutually beneficial environment, dysbiosis triggers chronic inflammation and compromises protective physical barriers. In the gastrointestinal tract, this manifests as increased intestinal permeability, or "leaky gut," facilitating the systemic translocation of microbial molecules. Similar imbalances in the skin and oral cavity are increasingly linked to chronic eczema and dental caries, respectively. While the microbiome is generally stable, it remains highly sensitive to environmental insults, including diet, stress, and infection. Consequently, dysbiosis serves as both a sensitive indicator of disease progression and a promising target for therapeutic intervention.

The primary goal of this Research Topic is to bridge the gap between fundamental microbiome research and clinical application by exploring the profound influence of dysbiosis on immunological health. We seek to highlight novel discoveries linking microbial communities to systemic diseases, chronic infections, and variations in vaccine efficacy. A key focus of this collection is the exploration of complex interkingdom relationships and the adaptive mechanisms these ecosystems employ under pathological stressors. Furthermore, we aim to address the diagnostic challenges associated with "leaky gut" and its impact on multi-organ inflammatory conditions. We particularly welcome contributions that translate knowledge of dysbiosis into real-world clinical practice. This includes the identification of specific microbial signatures to predict disease onset and the discovery of novel bacterial species through advanced techniques, such as targeted full-length 16S rRNA analysis, for therapeutic purposes. By synthesizing these diverse perspectives, this Research Topic hopes to advance the development of personalized, microbiota-targeted interventions for chronic inflammatory and immunological disorders.

To this end, we welcome Original Research, Reviews, Systematic Reviews, Clinical Trials, Case Reports, Methods articles, Perspectives, and Hypothesis & Theory pieces that collectively span the full spectrum from bench discovery to bedside application.

Topics of interest include but are not limited to:
• Dysbiosis in several organs and clinical adaptations in diseases or conditions
• Gut permeability defect (leaky gut) in diagnosis, monitoring, and treatment
• Products involve in dysbiosis, leaky gut, and inflammation
• Multiple organ correlation or crosstalk
• The interkingdom relationship
• The basic principle and the clinical adaptation
• Dysbiosis and treatment (probiotics, prebiotics, synbiotics, short-chain fatty acid, and other agents)
• Non-bacterial dysbiosis

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Dysbiosis, Microbiome, Microbiota, Chronic Inflammation, Immunological Diseases, Gut Health, Intestinal Permeability, Immune Homeostasis, Leaky Gut, Interkingdom Interactions, Microbial Translocation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.